Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer's Patch T Follicular Helper Cells

Fei Teng, Christina N. Klinger, Krysta M. Felix, C. Pierce Bradley, Eric Wu, Nhan L. Tran, Yoshinori Umesaki, Hsin-Jung Joyce Wu

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Gut microbiota profoundly affect gut and systemic diseases, but the mechanism whereby microbiota affect systemic diseases is unclear. It is not known whether specific microbiota regulate T follicular helper (Tfh) cells, whose excessive responses can inflict antibody-mediated autoimmunity. Using the K/BxN autoimmune arthritis model, we demonstrated that Peyer's patch (PP) Tfh cells were essential for gut commensal segmented filamentous bacteria (SFB)-induced systemic arthritis despite the production of auto-antibodies predominantly occurring in systemic lymphoid tissues, not PPs. We determined that SFB, by driving differentiation and egress of PP Tfh cells into systemic sites, boosted systemic Tfh cell and auto-antibody responses that exacerbated arthritis. SFB induced PP Tfh cell differentiation by limiting the access of interleukin 2 to CD4+ T cells, thereby enhancing Tfh cell master regulator Bcl-6 in a dendritic cell-dependent manner. These findings showed that gut microbiota remotely regulated a systemic disease by driving the induction and egress of gut Tfh cells.

Original languageEnglish (US)
Pages (from-to)875-888
Number of pages14
JournalImmunity
Volume44
Issue number4
DOIs
StatePublished - Apr 19 2016

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Peyer's Patches
Helper-Inducer T-Lymphocytes
Arthritis
Microbiota
Bacteria
Antibody Formation
Lymphoid Tissue
Autoimmunity
Dendritic Cells
Interleukin-2
Gastrointestinal Microbiome
Cell Differentiation
T-Lymphocytes
Antibodies

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

Cite this

Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer's Patch T Follicular Helper Cells. / Teng, Fei; Klinger, Christina N.; Felix, Krysta M.; Bradley, C. Pierce; Wu, Eric; Tran, Nhan L.; Umesaki, Yoshinori; Wu, Hsin-Jung Joyce.

In: Immunity, Vol. 44, No. 4, 19.04.2016, p. 875-888.

Research output: Contribution to journalArticle

Teng, Fei ; Klinger, Christina N. ; Felix, Krysta M. ; Bradley, C. Pierce ; Wu, Eric ; Tran, Nhan L. ; Umesaki, Yoshinori ; Wu, Hsin-Jung Joyce. / Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer's Patch T Follicular Helper Cells. In: Immunity. 2016 ; Vol. 44, No. 4. pp. 875-888.
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