Halicylindramides A-C, Antifungal and Cytotoxic Depsipeptides from the Marine Sponge Halichondria cylindrata

Hong yu Li, Shigeki Matsunaga, Nobuhiro Fusetani

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Halicylindramides A-C (1–3) have been isolated from the Japanese marine sponge Halichondria cylindrata. They are tetradecapeptides with the N-terminus blocked by a formyl group and the C-terminus lactonized with a threonine residue. Their total structures including absolute stereochemistry were determined by a combination of spectral and chemical methods. Halicylindramides A-C were antifungal against Mortierella ramanniana and cytotoxic against P388 murine leukemia cells.

Original languageEnglish (US)
Pages (from-to)338-343
Number of pages6
JournalJournal of Medicinal Chemistry
Issue number2
StatePublished - Jan 1 1995


ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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