Halicylindramides A-C, antifungal and cytotoxic depsipeptides from the marine sponge Halichondria cylindrata

Hong Yu Li, S. Matsunaga, N. Fusetani

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Halicylindramides A-C (1-3) have been isolated from the Japanese marine sponge Halichondria cylindrata. They are tetradecapeptides with the N- terminus blocked by a formyl group and the C-terminus lactonized with a threonine residue. Their total structures including absolute stereochemistry were determined by a combination of spectral and chemical methods. Halicylindramides A-C were antifungal against Mortierella ramanniana and cytotoxic against P388 murine leukemia cells.

Original languageEnglish (US)
Pages (from-to)338-343
Number of pages6
JournalJournal of Medicinal Chemistry
Volume38
Issue number2
DOIs
StatePublished - 1995
Externally publishedYes

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Depsipeptides
Porifera
Mortierella
Leukemia P388
Military Personnel
Threonine
halicylindramide A

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Cite this

Halicylindramides A-C, antifungal and cytotoxic depsipeptides from the marine sponge Halichondria cylindrata. / Li, Hong Yu; Matsunaga, S.; Fusetani, N.

In: Journal of Medicinal Chemistry, Vol. 38, No. 2, 1995, p. 338-343.

Research output: Contribution to journalArticle

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