Halicylindramides D and E, antifungal peptides from the marine sponge Halichondria cylindrata

Hong Yu Li, Shigeki Matsunaga, Nobuhiro Fusetani

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Halicylindramides D (1) and E (2) have been isolated from the marine sponge Halichondria cylindrata. Halicylindramide D is a tridecapeptide with the N-terminus blocked by a formyl group and the C-terminus lactonized with a threonine residue, while halicylindramide E is a truncated linear peptide with a C-terminal amide. Their structures, including absolute stereochemistry, were determined by a combination of spectral and chemical methods. Halicylindramide D was antifungal against Mortierella ramanniana and cytotoxic against P-388 murine leukemia cells.

Original languageEnglish (US)
Pages (from-to)163-166
Number of pages4
JournalJournal of Natural Products
Volume59
Issue number2
DOIs
StatePublished - Feb 1996
Externally publishedYes

Fingerprint

Porifera
Peptides
Mortierella
Stereochemistry
Threonine
Amides
Leukemia
halicylindramide E
halicylindramide D

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Halicylindramides D and E, antifungal peptides from the marine sponge Halichondria cylindrata. / Li, Hong Yu; Matsunaga, Shigeki; Fusetani, Nobuhiro.

In: Journal of Natural Products, Vol. 59, No. 2, 02.1996, p. 163-166.

Research output: Contribution to journalArticle

Li, Hong Yu ; Matsunaga, Shigeki ; Fusetani, Nobuhiro. / Halicylindramides D and E, antifungal peptides from the marine sponge Halichondria cylindrata. In: Journal of Natural Products. 1996 ; Vol. 59, No. 2. pp. 163-166.
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