Halicylindramides D and E, antifungal peptides from the marine sponge Halichondria cylindrata

Hong Yu Li, Shigeki Matsunaga, Nobuhiro Fusetani

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Halicylindramides D (1) and E (2) have been isolated from the marine sponge Halichondria cylindrata. Halicylindramide D is a tridecapeptide with the N-terminus blocked by a formyl group and the C-terminus lactonized with a threonine residue, while halicylindramide E is a truncated linear peptide with a C-terminal amide. Their structures, including absolute stereochemistry, were determined by a combination of spectral and chemical methods. Halicylindramide D was antifungal against Mortierella ramanniana and cytotoxic against P-388 murine leukemia cells.

Original languageEnglish (US)
Pages (from-to)163-166
Number of pages4
JournalJournal Of Natural Products
Volume59
Issue number2
DOIs
StatePublished - Feb 1 1996

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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