Halothane biotransformation in obese and nonobese patients

J. B. Bentley, R. W. Vaughan, A Jay Gandolfi, R. C. Cork

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Serum levels of inorganic fluoride, trifluroacetic acid, and bromide ion were measured at various time intervals following two hours of halothane anesthesia in 17 morbidly obese and eight nonobese patients. Ionic fluoride, a marker of reductive halothane metabolism, increased in the obese but not the nonobese patients. This is of concern since reductive halothane metabolism is associated with hepatoxicity in animals. In addition, serum bromide levels were higher after 48 hr in the obese patients compared to the nonobese patients (mean ± SE, 1,311 ± 114 vs. 787 ± 115 μM, P < 0.01). Sedative levels of bromide were not attained in any patient. Peak trifluoracetic acid levels were similar in the two patient groups. Sex, age, medication intake, and smoking history had no influence on the halothane metabolite levels found in this study.

Original languageEnglish (US)
Pages (from-to)94-97
Number of pages4
JournalAnesthesiology
Volume57
Issue number2
StatePublished - 1982

Fingerprint

Halothane
Biotransformation
Bromides
Fluorides
Acids
Serum
Hypnotics and Sedatives
Anesthesia
Smoking
History
Ions

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Bentley, J. B., Vaughan, R. W., Gandolfi, A. J., & Cork, R. C. (1982). Halothane biotransformation in obese and nonobese patients. Anesthesiology, 57(2), 94-97.

Halothane biotransformation in obese and nonobese patients. / Bentley, J. B.; Vaughan, R. W.; Gandolfi, A Jay; Cork, R. C.

In: Anesthesiology, Vol. 57, No. 2, 1982, p. 94-97.

Research output: Contribution to journalArticle

Bentley, JB, Vaughan, RW, Gandolfi, AJ & Cork, RC 1982, 'Halothane biotransformation in obese and nonobese patients', Anesthesiology, vol. 57, no. 2, pp. 94-97.
Bentley, J. B. ; Vaughan, R. W. ; Gandolfi, A Jay ; Cork, R. C. / Halothane biotransformation in obese and nonobese patients. In: Anesthesiology. 1982 ; Vol. 57, No. 2. pp. 94-97.
@article{7086a52aac26478f81fd742ee3a09a10,
title = "Halothane biotransformation in obese and nonobese patients",
abstract = "Serum levels of inorganic fluoride, trifluroacetic acid, and bromide ion were measured at various time intervals following two hours of halothane anesthesia in 17 morbidly obese and eight nonobese patients. Ionic fluoride, a marker of reductive halothane metabolism, increased in the obese but not the nonobese patients. This is of concern since reductive halothane metabolism is associated with hepatoxicity in animals. In addition, serum bromide levels were higher after 48 hr in the obese patients compared to the nonobese patients (mean ± SE, 1,311 ± 114 vs. 787 ± 115 μM, P < 0.01). Sedative levels of bromide were not attained in any patient. Peak trifluoracetic acid levels were similar in the two patient groups. Sex, age, medication intake, and smoking history had no influence on the halothane metabolite levels found in this study.",
author = "Bentley, {J. B.} and Vaughan, {R. W.} and Gandolfi, {A Jay} and Cork, {R. C.}",
year = "1982",
language = "English (US)",
volume = "57",
pages = "94--97",
journal = "Anesthesiology",
issn = "0003-3022",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Halothane biotransformation in obese and nonobese patients

AU - Bentley, J. B.

AU - Vaughan, R. W.

AU - Gandolfi, A Jay

AU - Cork, R. C.

PY - 1982

Y1 - 1982

N2 - Serum levels of inorganic fluoride, trifluroacetic acid, and bromide ion were measured at various time intervals following two hours of halothane anesthesia in 17 morbidly obese and eight nonobese patients. Ionic fluoride, a marker of reductive halothane metabolism, increased in the obese but not the nonobese patients. This is of concern since reductive halothane metabolism is associated with hepatoxicity in animals. In addition, serum bromide levels were higher after 48 hr in the obese patients compared to the nonobese patients (mean ± SE, 1,311 ± 114 vs. 787 ± 115 μM, P < 0.01). Sedative levels of bromide were not attained in any patient. Peak trifluoracetic acid levels were similar in the two patient groups. Sex, age, medication intake, and smoking history had no influence on the halothane metabolite levels found in this study.

AB - Serum levels of inorganic fluoride, trifluroacetic acid, and bromide ion were measured at various time intervals following two hours of halothane anesthesia in 17 morbidly obese and eight nonobese patients. Ionic fluoride, a marker of reductive halothane metabolism, increased in the obese but not the nonobese patients. This is of concern since reductive halothane metabolism is associated with hepatoxicity in animals. In addition, serum bromide levels were higher after 48 hr in the obese patients compared to the nonobese patients (mean ± SE, 1,311 ± 114 vs. 787 ± 115 μM, P < 0.01). Sedative levels of bromide were not attained in any patient. Peak trifluoracetic acid levels were similar in the two patient groups. Sex, age, medication intake, and smoking history had no influence on the halothane metabolite levels found in this study.

UR - http://www.scopus.com/inward/record.url?scp=0019978350&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019978350&partnerID=8YFLogxK

M3 - Article

VL - 57

SP - 94

EP - 97

JO - Anesthesiology

JF - Anesthesiology

SN - 0003-3022

IS - 2

ER -