HDAC activity is required for efficient core promoter function at the mouse mammary tumor virus promoter

Catharine L. Smith, Sang C. Lee, Angeliki Magklara

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Histone deacetylases (HDACs) have been shown to be required for basal or inducible transcription at a variety of genes by poorly understood mechanisms. We demonstrated previously that HDAC inhibition rapidly repressed transcription from the mouse mammary tumor virus (MMTV) promoter by a mechanism that does not require the binding of upstream transcription factors. In the current study, we find that HDACs work through the core promoter sequences of MMTV as well as those of several cellular genes to facilitate transcriptional initiation through deacetylation of nonhistone proteins.

Original languageEnglish (US)
Article number416905
JournalJournal of Biomedicine and Biotechnology
Volume2011
DOIs
StatePublished - Mar 8 2011

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

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