HDL-Cholesterol and Incidence of Breast Cancer in the ARIC Cohort Study

Anna M. Kucharska-Newton, Wayne D. Rosamond, Pamela J. Mink, Anthony J. Alberg, Eyal Shahar, Aaron R. Folsom

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Purpose: An association of low plasma HDL-cholesterol with risk of breast cancer has been suggested by multiple studies; the evidence, however, is not conclusive. We examined the possible association of low HDL-cholesterol with incidence of breast cancer using data from the Atherosclerosis Risk in Communities Study (ARIC) cohort, a prospective study of a randomly selected sample of women and men from four U.S. communities. Methods: Among 7,575 female members of the ARIC cohort, 359 cases of incident breast cancer were ascertained during the follow-up from 1987 through 2000. Results: In analysis adjusted for age, race, body mass index, smoking, and reproductive variables, we observed no association of low baseline HDL-cholesterol (<50 mg/dL) with incident breast cancer in the total sample (hazard ratio [HR] = 1.08 [95% confidence interval (CI), 0.84-1.40]) and a modest association (HR = 1.67 [95% CI, 1.06-2.63]) among women who were premenopausal at baseline. No association was observed among women who were postmenopausal at baseline. Removal from analysis of the first 5 years of follow-up did not appreciably change the observed associations. Conclusion: Results of our study suggest that low HDL-cholesterol among premenopausal women may be a marker of increased breast cancer risk.

Original languageEnglish (US)
Pages (from-to)671-677
Number of pages7
JournalAnnals of Epidemiology
Volume18
Issue number9
DOIs
StatePublished - Sep 2008

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HDL Cholesterol
Atherosclerosis
Cohort Studies
Breast Neoplasms
Incidence
Confidence Intervals
Body Mass Index
Smoking
Prospective Studies

Keywords

  • Breast Neoplasms
  • Cholesterol
  • Cohort Studies
  • HDL
  • Incidence

ASJC Scopus subject areas

  • Medicine(all)
  • Public Health, Environmental and Occupational Health
  • Epidemiology

Cite this

Kucharska-Newton, A. M., Rosamond, W. D., Mink, P. J., Alberg, A. J., Shahar, E., & Folsom, A. R. (2008). HDL-Cholesterol and Incidence of Breast Cancer in the ARIC Cohort Study. Annals of Epidemiology, 18(9), 671-677. https://doi.org/10.1016/j.annepidem.2008.06.006

HDL-Cholesterol and Incidence of Breast Cancer in the ARIC Cohort Study. / Kucharska-Newton, Anna M.; Rosamond, Wayne D.; Mink, Pamela J.; Alberg, Anthony J.; Shahar, Eyal; Folsom, Aaron R.

In: Annals of Epidemiology, Vol. 18, No. 9, 09.2008, p. 671-677.

Research output: Contribution to journalArticle

Kucharska-Newton, AM, Rosamond, WD, Mink, PJ, Alberg, AJ, Shahar, E & Folsom, AR 2008, 'HDL-Cholesterol and Incidence of Breast Cancer in the ARIC Cohort Study', Annals of Epidemiology, vol. 18, no. 9, pp. 671-677. https://doi.org/10.1016/j.annepidem.2008.06.006
Kucharska-Newton, Anna M. ; Rosamond, Wayne D. ; Mink, Pamela J. ; Alberg, Anthony J. ; Shahar, Eyal ; Folsom, Aaron R. / HDL-Cholesterol and Incidence of Breast Cancer in the ARIC Cohort Study. In: Annals of Epidemiology. 2008 ; Vol. 18, No. 9. pp. 671-677.
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