Healing enhancement of diabetic wounds by locally infiltrated epidermal growth factor is associated with systemic oxidative stress reduction

Ariana García Ojalvo, Jorge Berlanga Acosta, Yssel Mendoza Marí, Maday Fernández Mayola, Calixto Valdés Pérez, William Savigne Gutiérrez, Ileydis Iglesias Marichal, Eduardo Álvarez Seijas, Alicia Molina Kautzman, Angélica Estrada Pacheco, David G Armstrong

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The diabetic foot ulcer (DFU) is the leading cause of lower extremity amputation worldwide and is directly associated with comorbidity, disability and mortality. Oxidative stress mechanisms have been implicated in the pathogenesis of these wounds. Intra-lesional infiltration of epidermal growth factor has emerged as a potential therapeutic alternative to allow for physiological benefit while avoiding the proteolytic environment at the centre of the wound. The aim of this study was to characterise the response of patients with DFUs to epidermal growth factor treatment in terms of redox status markers. Experimental groups included patients with DFUs before and 3-4 weeks after starting treatment with epidermal growth factor; compensated and non-compensated diabetic patients without ulcers; and age-matched non-diabetic subjects. Evaluations comprised serum levels of oxidative stress and antioxidant reserve markers. Patients with DFUs exhibited the most disheveled biochemical profile, with elevated oxidative stress and low antioxidant reserves, with respect to non-ulcerated diabetic patients and to non-diabetic subjects. Epidermal growth factor intra-lesional administration was associated with a significant recovery of oxidative stress and antioxidant reserve markers. Altogether, our results indicate that epidermal growth factor intra-ulcer therapy contributes to restore systemic redox balance in patients with DFUs.

Original languageEnglish (US)
JournalInternational Wound Journal
DOIs
StateAccepted/In press - 2016

Keywords

  • Diabetes
  • Diabetes complications
  • Diabetic foot ulcers
  • Epidermal growth factor
  • Oxidative stress

ASJC Scopus subject areas

  • Surgery
  • Dermatology

Fingerprint Dive into the research topics of 'Healing enhancement of diabetic wounds by locally infiltrated epidermal growth factor is associated with systemic oxidative stress reduction'. Together they form a unique fingerprint.

  • Cite this

    Ojalvo, A. G., Acosta, J. B., Marí, Y. M., Mayola, M. F., Pérez, C. V., Gutiérrez, W. S., Marichal, I. I., Seijas, E. Á., Kautzman, A. M., Pacheco, A. E., & Armstrong, D. G. (Accepted/In press). Healing enhancement of diabetic wounds by locally infiltrated epidermal growth factor is associated with systemic oxidative stress reduction. International Wound Journal. https://doi.org/10.1111/iwj.12592