Health-related quality of life among long-term rectal cancer survivors with an ostomy: Manifestations by sex

Robert S Krouse, Lisa J. Herrinton, Marcia Grant, Christopher S Wendel, Sylvan B. Green, Martha J Mohler, Carol M. Baldwin, Carmit K. McMullen, Susan M. Rawl, Eric Matayoshi, Stephen Joel Coons, Mark C. Hornbrook

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

Purpose: Intestinal stomas can pose significant challenges for long-term (≥ 5 years) rectal cancer (RC) survivors. Specifying common challenges and sociodemographic or clinical differences will further the development of tailored interventions to improve health-related quality of life (HRQOL). Patients and Methods: This was a matched cross-sectional study of long-term RC survivors conducted in three Kaiser Permanente regions. The mailed questionnaire included the modified City of Hope Quality of Life-Ostomy (mCOH-QOLOstomy) and Medical Outcomes Study 36-Item Short-Form Health Survey, version 2 (SF-36v2). Groups surveyed were permanent ostomates (cases) and those who did not require an ostomy (controls). RC survivors were matched on sex, age, and time since diagnosis. Comparisons between groups used regression analysis with adjustment for age, comorbidity score, history of radiation therapy, income, and work status. Results: Response rate was 54% (491 of 909). Cases and controls had similar demographic characteristics. On the basis of the mCOH-QOL-Ostomy, both male and female cases had significantly worse social well-being compared with controls, while only female cases reported significantly worse overall HRQOL and psychological well-being. For younger females (< age 75 years), ostomy had a greater impact on physical well-being compared with older females. Based on the SF-36v2, statistically significant and meaningful differences between female cases and controls were observed for seven of the eight scales and on the physical and mental component summary scores. Conclusion: Men and women report a different profile of challenges, suggesting the need for targeted or sex-specific interventions to improve HRQOL in this population. This may include focus on physical HRQOL for female ostomy survivors younger than age 75.

Original languageEnglish (US)
Pages (from-to)1664-4670
Number of pages3007
JournalJournal of Clinical Oncology
Volume27
Issue number28
DOIs
StatePublished - Oct 1 2009
Externally publishedYes

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Ostomy
Rectal Neoplasms
Survivors
Quality of Life
Health Surveys
Comorbidity
Radiotherapy
Cross-Sectional Studies
Regression Analysis
Demography
Outcome Assessment (Health Care)
Psychology
Population

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Health-related quality of life among long-term rectal cancer survivors with an ostomy : Manifestations by sex. / Krouse, Robert S; Herrinton, Lisa J.; Grant, Marcia; Wendel, Christopher S; Green, Sylvan B.; Mohler, Martha J; Baldwin, Carol M.; McMullen, Carmit K.; Rawl, Susan M.; Matayoshi, Eric; Coons, Stephen Joel; Hornbrook, Mark C.

In: Journal of Clinical Oncology, Vol. 27, No. 28, 01.10.2009, p. 1664-4670.

Research output: Contribution to journalArticle

Krouse, RS, Herrinton, LJ, Grant, M, Wendel, CS, Green, SB, Mohler, MJ, Baldwin, CM, McMullen, CK, Rawl, SM, Matayoshi, E, Coons, SJ & Hornbrook, MC 2009, 'Health-related quality of life among long-term rectal cancer survivors with an ostomy: Manifestations by sex', Journal of Clinical Oncology, vol. 27, no. 28, pp. 1664-4670. https://doi.org/10.1200/JCO.2008.20.9502
Krouse, Robert S ; Herrinton, Lisa J. ; Grant, Marcia ; Wendel, Christopher S ; Green, Sylvan B. ; Mohler, Martha J ; Baldwin, Carol M. ; McMullen, Carmit K. ; Rawl, Susan M. ; Matayoshi, Eric ; Coons, Stephen Joel ; Hornbrook, Mark C. / Health-related quality of life among long-term rectal cancer survivors with an ostomy : Manifestations by sex. In: Journal of Clinical Oncology. 2009 ; Vol. 27, No. 28. pp. 1664-4670.
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AU - Herrinton, Lisa J.

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AU - Wendel, Christopher S

AU - Green, Sylvan B.

AU - Mohler, Martha J

AU - Baldwin, Carol M.

AU - McMullen, Carmit K.

AU - Rawl, Susan M.

AU - Matayoshi, Eric

AU - Coons, Stephen Joel

AU - Hornbrook, Mark C.

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