Health utilities associated with hemoglobin levels and blood loss in postmenopausal women: The women's health initiative

Brooke S. Harrow, C. B. Eaton, M. B. Roberts, A. R. Assaf, Xuemei Luo, Zhao Chen

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Objectives: The purpose of our study was to use health-related quality of clife data from the Women's Health Initiative to calculate health-related utility weights and examine differences in these health utility weights across different hemoglobin (Hgb) levels. These utility weights could then be used in future cost-effectiveness studies. Methods: Health utility weights were measured by the Short Form-6D (SF-6D), a health utility index derived from the Short Form Medical Outcomes questionnaire. Adjusted least square means were calculated for each level of Hgb at baseline and in longitudinal regression analysis the relationship between change in Hgb and change in the SF-6D was examined. Both baseline and longitudinal analyses were performed for all postmenopausal women and separately for those with self-reported heart failure, cancer, and osteoarthritis. Results: Womenwith Hgb in the anemic range had lower health utility weights than those with higher Hgb levels. Longitudinally, a loss of of 2 g/dl Hgb or more was associated with a statistically significant and clinically meaningfully decline in SF-6D in all participants and also in the group of participants with cancer and osteoarthritis, but not in those with heart failure. Conclusions: Lower levels of Hgb and a loss of Hgb are associated with a statistically significant and clinically meaningful decrement in health utility in all postmenopausal women we studied and also in those with chronic conditions.

Original languageEnglish (US)
Pages (from-to)555-563
Number of pages9
JournalValue in Health
Volume14
Issue number4
DOIs
StatePublished - Jun 2011

Keywords

  • Health utilities
  • Osteoarthritis
  • Postmenopausal
  • hgb

ASJC Scopus subject areas

  • Health Policy
  • Public Health, Environmental and Occupational Health

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