Heart disease, methamphetamine and AIDS

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Methamphetamine (MA) not only affects the nervous system but also has cardiac toxicity and immunosuppressive properties. This manuscript will provide support that there is a relationship between MA use and heart disease as well as immune dysfunction. The cardiovascular manifestations of acute MA use include tachycardia, atrioventricular arrhythmias, myocardial ischemia, myocardial ischemia and hypertension, resulting in cardiac lesions. Chronic use of MA causes cardiomyopathy including cellular infiltration, myocardial hypertrophy, myocardium rupture and fibrosis. The increased catecholamine levels are responsible for the cardiac lesions induced by MA. The additional problem with MA use is its potential to disrupt the immune system function leading to suppression of mitogen-stimulated lymphocyte, a reduction in circulating lymphocyte numbers and alternation T-lymphocyte cytokine secretion as well as B cell proinflammatory cytokine secretion. Concomitant MA use and Human Immunodeficiency Virus (HIV) infection not only enhances immunosuppression associated with HIV but also increases the heart disease occurrence with a coincidentally complication of AIDS or AIDS medications.

Original languageEnglish (US)
Pages (from-to)129-140
Number of pages12
JournalLife Sciences
Volume73
Issue number2
DOIs
StatePublished - May 30 2003

Fingerprint

Methamphetamine
Heart Diseases
Acquired Immunodeficiency Syndrome
Lymphocytes
Viruses
Myocardial Ischemia
HIV
Cytokines
T-cells
Immune system
Lymphocyte Count
Neurology
Virus Diseases
Immunosuppressive Agents
Cardiomyopathies
Mitogens
Infiltration
Tachycardia
Immunosuppression
Hypertrophy

Keywords

  • AIDS
  • Heart disease
  • HIV
  • Methamphetamine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Heart disease, methamphetamine and AIDS. / Yu, Qianli; Larson, Douglas F; Watson, Ronald R.

In: Life Sciences, Vol. 73, No. 2, 30.05.2003, p. 129-140.

Research output: Contribution to journalArticle

@article{cc3f5d7b59b24582977935f9d7fd2be4,
title = "Heart disease, methamphetamine and AIDS",
abstract = "Methamphetamine (MA) not only affects the nervous system but also has cardiac toxicity and immunosuppressive properties. This manuscript will provide support that there is a relationship between MA use and heart disease as well as immune dysfunction. The cardiovascular manifestations of acute MA use include tachycardia, atrioventricular arrhythmias, myocardial ischemia, myocardial ischemia and hypertension, resulting in cardiac lesions. Chronic use of MA causes cardiomyopathy including cellular infiltration, myocardial hypertrophy, myocardium rupture and fibrosis. The increased catecholamine levels are responsible for the cardiac lesions induced by MA. The additional problem with MA use is its potential to disrupt the immune system function leading to suppression of mitogen-stimulated lymphocyte, a reduction in circulating lymphocyte numbers and alternation T-lymphocyte cytokine secretion as well as B cell proinflammatory cytokine secretion. Concomitant MA use and Human Immunodeficiency Virus (HIV) infection not only enhances immunosuppression associated with HIV but also increases the heart disease occurrence with a coincidentally complication of AIDS or AIDS medications.",
keywords = "AIDS, Heart disease, HIV, Methamphetamine",
author = "Qianli Yu and Larson, {Douglas F} and Watson, {Ronald R}",
year = "2003",
month = "5",
day = "30",
doi = "10.1016/S0024-3205(03)00260-1",
language = "English (US)",
volume = "73",
pages = "129--140",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Heart disease, methamphetamine and AIDS

AU - Yu, Qianli

AU - Larson, Douglas F

AU - Watson, Ronald R

PY - 2003/5/30

Y1 - 2003/5/30

N2 - Methamphetamine (MA) not only affects the nervous system but also has cardiac toxicity and immunosuppressive properties. This manuscript will provide support that there is a relationship between MA use and heart disease as well as immune dysfunction. The cardiovascular manifestations of acute MA use include tachycardia, atrioventricular arrhythmias, myocardial ischemia, myocardial ischemia and hypertension, resulting in cardiac lesions. Chronic use of MA causes cardiomyopathy including cellular infiltration, myocardial hypertrophy, myocardium rupture and fibrosis. The increased catecholamine levels are responsible for the cardiac lesions induced by MA. The additional problem with MA use is its potential to disrupt the immune system function leading to suppression of mitogen-stimulated lymphocyte, a reduction in circulating lymphocyte numbers and alternation T-lymphocyte cytokine secretion as well as B cell proinflammatory cytokine secretion. Concomitant MA use and Human Immunodeficiency Virus (HIV) infection not only enhances immunosuppression associated with HIV but also increases the heart disease occurrence with a coincidentally complication of AIDS or AIDS medications.

AB - Methamphetamine (MA) not only affects the nervous system but also has cardiac toxicity and immunosuppressive properties. This manuscript will provide support that there is a relationship between MA use and heart disease as well as immune dysfunction. The cardiovascular manifestations of acute MA use include tachycardia, atrioventricular arrhythmias, myocardial ischemia, myocardial ischemia and hypertension, resulting in cardiac lesions. Chronic use of MA causes cardiomyopathy including cellular infiltration, myocardial hypertrophy, myocardium rupture and fibrosis. The increased catecholamine levels are responsible for the cardiac lesions induced by MA. The additional problem with MA use is its potential to disrupt the immune system function leading to suppression of mitogen-stimulated lymphocyte, a reduction in circulating lymphocyte numbers and alternation T-lymphocyte cytokine secretion as well as B cell proinflammatory cytokine secretion. Concomitant MA use and Human Immunodeficiency Virus (HIV) infection not only enhances immunosuppression associated with HIV but also increases the heart disease occurrence with a coincidentally complication of AIDS or AIDS medications.

KW - AIDS

KW - Heart disease

KW - HIV

KW - Methamphetamine

UR - http://www.scopus.com/inward/record.url?scp=0038555823&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038555823&partnerID=8YFLogxK

U2 - 10.1016/S0024-3205(03)00260-1

DO - 10.1016/S0024-3205(03)00260-1

M3 - Article

C2 - 12738029

AN - SCOPUS:0038555823

VL - 73

SP - 129

EP - 140

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 2

ER -