Heart rate and heart rate variability changes in the intracarotid sodium amobarbital test

Geoffrey L Ahern, John J. Sollers, Richard D Lane, David M Labiner, Anne M. Herring, Martin E Weinand, Ronald Hutzler, Julian F. Thayer

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

Purpose: Changes in heart rate and heart rate variability have been found in prior studies performed during the intracarotid sodium amobarbital (ISA) test. However, these results are not entirely consistent with current models of differential cerebral involvement in the modulation of the heart. This study was designed to re-investigate this topic with a larger N than has heretofore been used. Methods: The electrocardiogram was recorded during left and right ISAs in 73 subjects. Raw heart rate and heart rate variability were calculated. Results: Raw heart rate increased during inactivation of either hemisphere, but more so for the right hemisphere. Heart rate variability changes consistent with decreasing parasympathetic tone also were found to occur during either ISA, but to a significant degree, only during right ISA. Conclusions: The right hemisphere appears to have a greater role in cerebral regulation of cardiac function, perhaps by virtue of the modification of parasympathetic effects.

Original languageEnglish (US)
Pages (from-to)912-921
Number of pages10
JournalEpilepsia
Volume42
Issue number7
DOIs
StatePublished - 2001

Fingerprint

Amobarbital
Heart Rate
Electrocardiography

Keywords

  • Autonomic nervous system
  • Heart rate
  • Heart rate variability
  • Intracarotid sodium amobarbital test
  • Wada test

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Heart rate and heart rate variability changes in the intracarotid sodium amobarbital test. / Ahern, Geoffrey L; Sollers, John J.; Lane, Richard D; Labiner, David M; Herring, Anne M.; Weinand, Martin E; Hutzler, Ronald; Thayer, Julian F.

In: Epilepsia, Vol. 42, No. 7, 2001, p. 912-921.

Research output: Contribution to journalArticle

Ahern, Geoffrey L ; Sollers, John J. ; Lane, Richard D ; Labiner, David M ; Herring, Anne M. ; Weinand, Martin E ; Hutzler, Ronald ; Thayer, Julian F. / Heart rate and heart rate variability changes in the intracarotid sodium amobarbital test. In: Epilepsia. 2001 ; Vol. 42, No. 7. pp. 912-921.
@article{d1f87734a8ac4879a82d3249d67fe64b,
title = "Heart rate and heart rate variability changes in the intracarotid sodium amobarbital test",
abstract = "Purpose: Changes in heart rate and heart rate variability have been found in prior studies performed during the intracarotid sodium amobarbital (ISA) test. However, these results are not entirely consistent with current models of differential cerebral involvement in the modulation of the heart. This study was designed to re-investigate this topic with a larger N than has heretofore been used. Methods: The electrocardiogram was recorded during left and right ISAs in 73 subjects. Raw heart rate and heart rate variability were calculated. Results: Raw heart rate increased during inactivation of either hemisphere, but more so for the right hemisphere. Heart rate variability changes consistent with decreasing parasympathetic tone also were found to occur during either ISA, but to a significant degree, only during right ISA. Conclusions: The right hemisphere appears to have a greater role in cerebral regulation of cardiac function, perhaps by virtue of the modification of parasympathetic effects.",
keywords = "Autonomic nervous system, Heart rate, Heart rate variability, Intracarotid sodium amobarbital test, Wada test",
author = "Ahern, {Geoffrey L} and Sollers, {John J.} and Lane, {Richard D} and Labiner, {David M} and Herring, {Anne M.} and Weinand, {Martin E} and Ronald Hutzler and Thayer, {Julian F.}",
year = "2001",
doi = "10.1046/j.1528-1157.2001.042007912.x",
language = "English (US)",
volume = "42",
pages = "912--921",
journal = "Epilepsia",
issn = "0013-9580",
publisher = "Wiley-Blackwell",
number = "7",

}

TY - JOUR

T1 - Heart rate and heart rate variability changes in the intracarotid sodium amobarbital test

AU - Ahern, Geoffrey L

AU - Sollers, John J.

AU - Lane, Richard D

AU - Labiner, David M

AU - Herring, Anne M.

AU - Weinand, Martin E

AU - Hutzler, Ronald

AU - Thayer, Julian F.

PY - 2001

Y1 - 2001

N2 - Purpose: Changes in heart rate and heart rate variability have been found in prior studies performed during the intracarotid sodium amobarbital (ISA) test. However, these results are not entirely consistent with current models of differential cerebral involvement in the modulation of the heart. This study was designed to re-investigate this topic with a larger N than has heretofore been used. Methods: The electrocardiogram was recorded during left and right ISAs in 73 subjects. Raw heart rate and heart rate variability were calculated. Results: Raw heart rate increased during inactivation of either hemisphere, but more so for the right hemisphere. Heart rate variability changes consistent with decreasing parasympathetic tone also were found to occur during either ISA, but to a significant degree, only during right ISA. Conclusions: The right hemisphere appears to have a greater role in cerebral regulation of cardiac function, perhaps by virtue of the modification of parasympathetic effects.

AB - Purpose: Changes in heart rate and heart rate variability have been found in prior studies performed during the intracarotid sodium amobarbital (ISA) test. However, these results are not entirely consistent with current models of differential cerebral involvement in the modulation of the heart. This study was designed to re-investigate this topic with a larger N than has heretofore been used. Methods: The electrocardiogram was recorded during left and right ISAs in 73 subjects. Raw heart rate and heart rate variability were calculated. Results: Raw heart rate increased during inactivation of either hemisphere, but more so for the right hemisphere. Heart rate variability changes consistent with decreasing parasympathetic tone also were found to occur during either ISA, but to a significant degree, only during right ISA. Conclusions: The right hemisphere appears to have a greater role in cerebral regulation of cardiac function, perhaps by virtue of the modification of parasympathetic effects.

KW - Autonomic nervous system

KW - Heart rate

KW - Heart rate variability

KW - Intracarotid sodium amobarbital test

KW - Wada test

UR - http://www.scopus.com/inward/record.url?scp=0034857298&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034857298&partnerID=8YFLogxK

U2 - 10.1046/j.1528-1157.2001.042007912.x

DO - 10.1046/j.1528-1157.2001.042007912.x

M3 - Article

C2 - 11488892

AN - SCOPUS:0034857298

VL - 42

SP - 912

EP - 921

JO - Epilepsia

JF - Epilepsia

SN - 0013-9580

IS - 7

ER -