Heat-induced denaturation of collagenous tissue

A comparison of numerical simulations with OCT and MRI data

Alptekin Aksan, Arthur F Gmitro, Jennifer K Barton, Scott Anseth, Steven P. Arnoczky, Damien J. Fron, John J. McGrath

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Application of sub-ablative levels of heat to collagenous tissues has important therapeutic applications in medicine, such as tissue welding, thermokeratoplasty, skin resurfacing and treatment of joint instability. Sub-ablative heating produces collagen denaturation with desired tissue shrinkage yet detrimental comprises in mechanical properties of the tissue. In this paper, results of preliminary analyses with Optical Coherence Tomography (OCT) and Magnetic Resonance Imaging (MRI) are compared with a numerical model of tissue denaturation.

Original languageEnglish (US)
Title of host publicationASME International Mechanical Engineering Congress and Exposition, Proceedings
PublisherAmerican Society of Mechanical Engineers (ASME)
Pages51-54
Number of pages4
ISBN (Print)0791836398, 9780791836392
DOIs
StatePublished - 2002

Fingerprint

Denaturation
Optical tomography
Tissue
Computer simulation
Collagen
Medicine
Numerical models
Skin
Welding
Hot Temperature
Magnetic Resonance Imaging
Heating
Mechanical properties

ASJC Scopus subject areas

  • Mechanical Engineering

Cite this

Aksan, A., Gmitro, A. F., Barton, J. K., Anseth, S., Arnoczky, S. P., Fron, D. J., & McGrath, J. J. (2002). Heat-induced denaturation of collagenous tissue: A comparison of numerical simulations with OCT and MRI data. In ASME International Mechanical Engineering Congress and Exposition, Proceedings (pp. 51-54). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/IMECE2002-33690

Heat-induced denaturation of collagenous tissue : A comparison of numerical simulations with OCT and MRI data. / Aksan, Alptekin; Gmitro, Arthur F; Barton, Jennifer K; Anseth, Scott; Arnoczky, Steven P.; Fron, Damien J.; McGrath, John J.

ASME International Mechanical Engineering Congress and Exposition, Proceedings. American Society of Mechanical Engineers (ASME), 2002. p. 51-54.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Aksan, A, Gmitro, AF, Barton, JK, Anseth, S, Arnoczky, SP, Fron, DJ & McGrath, JJ 2002, Heat-induced denaturation of collagenous tissue: A comparison of numerical simulations with OCT and MRI data. in ASME International Mechanical Engineering Congress and Exposition, Proceedings. American Society of Mechanical Engineers (ASME), pp. 51-54. https://doi.org/10.1115/IMECE2002-33690
Aksan A, Gmitro AF, Barton JK, Anseth S, Arnoczky SP, Fron DJ et al. Heat-induced denaturation of collagenous tissue: A comparison of numerical simulations with OCT and MRI data. In ASME International Mechanical Engineering Congress and Exposition, Proceedings. American Society of Mechanical Engineers (ASME). 2002. p. 51-54 https://doi.org/10.1115/IMECE2002-33690
Aksan, Alptekin ; Gmitro, Arthur F ; Barton, Jennifer K ; Anseth, Scott ; Arnoczky, Steven P. ; Fron, Damien J. ; McGrath, John J. / Heat-induced denaturation of collagenous tissue : A comparison of numerical simulations with OCT and MRI data. ASME International Mechanical Engineering Congress and Exposition, Proceedings. American Society of Mechanical Engineers (ASME), 2002. pp. 51-54
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