Heat-induced denaturation of collagenous tissue: A comparison of numerical simulations with OCT and MRI data

Alptekin Aksan, Arthur F. Gmitro, Jennifer K. Barton, Scott Anseth, Steven P. Arnoczky, Damien J. Fron, John J. McGrath

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Application of sub-ablative levels of heat to collagenous tissues has important therapeutic applications in medicine, such as tissue welding, thermokeratoplasty, skin resurfacing and treatment of joint instability. Sub-ablative heating produces collagen denaturation with desired tissue shrinkage yet detrimental comprises in mechanical properties of the tissue. In this paper, results of preliminary analyses with Optical Coherence Tomography (OCT) and Magnetic Resonance Imaging (MRI) are compared with a numerical model of tissue denaturation.

Original languageEnglish (US)
Title of host publicationAdvances in Heat and Mass Transfer in Biotechnology
PublisherAmerican Society of Mechanical Engineers (ASME)
Pages51-54
Number of pages4
ISBN (Print)0791836398, 9780791836392
DOIs
StatePublished - Jan 1 2002

Publication series

NameASME International Mechanical Engineering Congress and Exposition, Proceedings

ASJC Scopus subject areas

  • Mechanical Engineering

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    Aksan, A., Gmitro, A. F., Barton, J. K., Anseth, S., Arnoczky, S. P., Fron, D. J., & McGrath, J. J. (2002). Heat-induced denaturation of collagenous tissue: A comparison of numerical simulations with OCT and MRI data. In Advances in Heat and Mass Transfer in Biotechnology (pp. 51-54). (ASME International Mechanical Engineering Congress and Exposition, Proceedings). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/IMECE2002-33690