Helical Supramolecules and Fibers Utilizing Leucine Zipper-Displaying Dendrimers

Min Zhou, David Bentley, Indraneel Ghosh

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

We describe a new family of discrete supramolecules comprising leucine-zipper peptides noncovalently assembled upon cognate leucine zippers fused to a dendrimer core. Circular dichroism and sedimentation equilibrium experiments clearly demonstrate that each leucine-zipper dendrimer (D-EZ4 or D-KZ4) can noncovalently display four leucine zippers on their surface that can be utilized for the multivalent display of protein cargo. Furthermore, we show that matched leucine-zipper dendrimers (D-EZ4/D-KZ4) can self-organize into fibers at neutral pH, providing a new scaffold for nanotechnology.

Original languageEnglish (US)
Pages (from-to)734-735
Number of pages2
JournalJournal of the American Chemical Society
Volume126
Issue number3
DOIs
StatePublished - Jan 28 2004

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Dendrimers
Leucine Zippers
Fasteners
Fibers
Nanotechnology
Dichroism
Circular Dichroism
Sedimentation
Scaffolds
Peptides
Display devices
Proteins
Experiments

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Helical Supramolecules and Fibers Utilizing Leucine Zipper-Displaying Dendrimers. / Zhou, Min; Bentley, David; Ghosh, Indraneel.

In: Journal of the American Chemical Society, Vol. 126, No. 3, 28.01.2004, p. 734-735.

Research output: Contribution to journalArticle

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