Helical Supramolecules and Fibers Utilizing Leucine Zipper-Displaying Dendrimers

Min Zhou, David Bentley, Indraneel Ghosh

Research output: Contribution to journalArticle

87 Scopus citations

Abstract

We describe a new family of discrete supramolecules comprising leucine-zipper peptides noncovalently assembled upon cognate leucine zippers fused to a dendrimer core. Circular dichroism and sedimentation equilibrium experiments clearly demonstrate that each leucine-zipper dendrimer (D-EZ4 or D-KZ4) can noncovalently display four leucine zippers on their surface that can be utilized for the multivalent display of protein cargo. Furthermore, we show that matched leucine-zipper dendrimers (D-EZ4/D-KZ4) can self-organize into fibers at neutral pH, providing a new scaffold for nanotechnology.

Original languageEnglish (US)
Pages (from-to)734-735
Number of pages2
JournalJournal of the American Chemical Society
Volume126
Issue number3
DOIs
StatePublished - Jan 28 2004

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ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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