Hemeoxygenase-1 mediated hypercoagulability in a patient with thyroid cancer

Vance G Nielsen, Benjamin D. Garol, Eric A. Zelman, Marlon A Guerrero

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Thyroid cancers can cause significant regional thrombotic morbidity and mortality. Of interest, thyroid cancer cell lines can have upregulation of the carbon monoxide-producing enzyme, hemeoxygenase-1. Carbon monoxide has been demonstrated to markedly enhance plasmatic coagulation in vitro and in vivo via enhancement of fibrinogen's substrate properties by binding to a fibrinogen-associated heme group(s). We present a patient undergoing removal of a malignant thyroid tumour who was serendipitously found to have abnormally increased carboxyhaemoglobin concentration (2.4%) and plasmatic hypercoagulability with a carbon monoxide-mediated clot strength as determined by a thrombelastographic method. This initial observation serves as a rationale to further investigate the role played by hemeoxygenase-1 upregulation in the setting of cancers associated with increased endogenous carbon monoxide production.

Original languageEnglish (US)
Pages (from-to)663-665
Number of pages3
JournalBlood Coagulation and Fibrinolysis
Volume24
Issue number6
DOIs
StatePublished - Sep 2013

Fingerprint

Heme Oxygenase-1
Thrombophilia
Carbon Monoxide
Thyroid Neoplasms
Fibrinogen
Up-Regulation
Carboxyhemoglobin
Heme
Neoplasms
Thyroid Gland
Observation
Morbidity
Cell Line
Mortality
Enzymes

Keywords

  • carbon monoxide
  • hemeoxygenase-1
  • thrombelastography
  • thrombosis
  • thyroid cancer

ASJC Scopus subject areas

  • Hematology

Cite this

Hemeoxygenase-1 mediated hypercoagulability in a patient with thyroid cancer. / Nielsen, Vance G; Garol, Benjamin D.; Zelman, Eric A.; Guerrero, Marlon A.

In: Blood Coagulation and Fibrinolysis, Vol. 24, No. 6, 09.2013, p. 663-665.

Research output: Contribution to journalArticle

@article{e976f7dcb1b74b07891f9ce269f3e613,
title = "Hemeoxygenase-1 mediated hypercoagulability in a patient with thyroid cancer",
abstract = "Thyroid cancers can cause significant regional thrombotic morbidity and mortality. Of interest, thyroid cancer cell lines can have upregulation of the carbon monoxide-producing enzyme, hemeoxygenase-1. Carbon monoxide has been demonstrated to markedly enhance plasmatic coagulation in vitro and in vivo via enhancement of fibrinogen's substrate properties by binding to a fibrinogen-associated heme group(s). We present a patient undergoing removal of a malignant thyroid tumour who was serendipitously found to have abnormally increased carboxyhaemoglobin concentration (2.4{\%}) and plasmatic hypercoagulability with a carbon monoxide-mediated clot strength as determined by a thrombelastographic method. This initial observation serves as a rationale to further investigate the role played by hemeoxygenase-1 upregulation in the setting of cancers associated with increased endogenous carbon monoxide production.",
keywords = "carbon monoxide, hemeoxygenase-1, thrombelastography, thrombosis, thyroid cancer",
author = "Nielsen, {Vance G} and Garol, {Benjamin D.} and Zelman, {Eric A.} and Guerrero, {Marlon A}",
year = "2013",
month = "9",
doi = "10.1097/MBC.0b013e328363ab86",
language = "English (US)",
volume = "24",
pages = "663--665",
journal = "Blood Coagulation and Fibrinolysis",
issn = "0957-5235",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Hemeoxygenase-1 mediated hypercoagulability in a patient with thyroid cancer

AU - Nielsen, Vance G

AU - Garol, Benjamin D.

AU - Zelman, Eric A.

AU - Guerrero, Marlon A

PY - 2013/9

Y1 - 2013/9

N2 - Thyroid cancers can cause significant regional thrombotic morbidity and mortality. Of interest, thyroid cancer cell lines can have upregulation of the carbon monoxide-producing enzyme, hemeoxygenase-1. Carbon monoxide has been demonstrated to markedly enhance plasmatic coagulation in vitro and in vivo via enhancement of fibrinogen's substrate properties by binding to a fibrinogen-associated heme group(s). We present a patient undergoing removal of a malignant thyroid tumour who was serendipitously found to have abnormally increased carboxyhaemoglobin concentration (2.4%) and plasmatic hypercoagulability with a carbon monoxide-mediated clot strength as determined by a thrombelastographic method. This initial observation serves as a rationale to further investigate the role played by hemeoxygenase-1 upregulation in the setting of cancers associated with increased endogenous carbon monoxide production.

AB - Thyroid cancers can cause significant regional thrombotic morbidity and mortality. Of interest, thyroid cancer cell lines can have upregulation of the carbon monoxide-producing enzyme, hemeoxygenase-1. Carbon monoxide has been demonstrated to markedly enhance plasmatic coagulation in vitro and in vivo via enhancement of fibrinogen's substrate properties by binding to a fibrinogen-associated heme group(s). We present a patient undergoing removal of a malignant thyroid tumour who was serendipitously found to have abnormally increased carboxyhaemoglobin concentration (2.4%) and plasmatic hypercoagulability with a carbon monoxide-mediated clot strength as determined by a thrombelastographic method. This initial observation serves as a rationale to further investigate the role played by hemeoxygenase-1 upregulation in the setting of cancers associated with increased endogenous carbon monoxide production.

KW - carbon monoxide

KW - hemeoxygenase-1

KW - thrombelastography

KW - thrombosis

KW - thyroid cancer

UR - http://www.scopus.com/inward/record.url?scp=84882452207&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882452207&partnerID=8YFLogxK

U2 - 10.1097/MBC.0b013e328363ab86

DO - 10.1097/MBC.0b013e328363ab86

M3 - Article

C2 - 23817544

AN - SCOPUS:84882452207

VL - 24

SP - 663

EP - 665

JO - Blood Coagulation and Fibrinolysis

JF - Blood Coagulation and Fibrinolysis

SN - 0957-5235

IS - 6

ER -