Hemodilution with lactated Ringer's solution causes hypocoagulability in rabbits

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Hemodilution (HD) has been associated with hypercoagulability. It was hypothesized that HD with lactated Ringer's solution (LR) would result in hypercoagulability in rabbits. Sedated rabbits (n = 12) underwent HD with LR (40% estimated blood volume replaced with five volumes of LR) via ear vessels. Key procoagulants and anticoagulant activities were assessed prior to and 3 h after HD. Hemostatic function was assessed with the activated coagulation time and platelet-inhibited thrombelastography. Circulating tissue factor activity was much more diluted (-67.2% from baseline) than tissue factor pathway inhibitor (-45.2%) or antithrombin (-9.5%) activities after HD. HD significantly decreased factor VIII complex activity (-31.5%) more than protein C activity (-5.9%), and factor X activity (-29.2%) was more diluted than antithrombin activity. The activated coagulation time and thrombelastography demonstrated a significant decrease in hemostatic function after HD. Hemodilution with LR caused hypocoagulability in the rabbit A greater decrease in circulating procoagulant activity than anticoagulant activity appears to be the mechanism underlying HD-mediated decreases in hemostasis.

Original languageEnglish (US)
Pages (from-to)55-59
Number of pages5
JournalBlood Coagulation and Fibrinolysis
Volume15
Issue number1
DOIs
StatePublished - Jan 1 2004
Externally publishedYes

Keywords

  • Crystalloids
  • Factor VII
  • Factor VIII
  • Factor X
  • Hemodilution
  • Thrombelastography
  • Tissue factor
  • Tissue factor pathway inhibitor

ASJC Scopus subject areas

  • Hematology

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