Hemodynamic and thrombogenic analysis of a trileaflet polymeric valve using a fluid-structure interaction approach

Filippo Piatti, Francesco Sturla, Gil Marom, Jawaad Sheriff, Thomas E. Claiborne, Marvin J Slepian, Alberto Redaelli, Danny Bluestein

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Surgical valve replacement in patients with severe calcific aortic valve disease using either bioprosthetic or mechanical heart valves is still limited by structural valve deterioration for the former and thrombosis risk mandating anticoagulant therapy for the latter. Prosthetic polymeric heart valves have the potential to overcome the inherent material and design limitations of these valves, but their development is still ongoing. The aim of this study was to characterize the hemodynamics and thrombogenic potential of the Polynova polymeric trileaflet valve prototype using a fluid-structure interaction (FSI) approach. The FSI model replicated experimental conditions of the valve as tested in a left heart simulator. Hemodynamic parameters (transvalvular pressure gradient, flow rate, maximum velocity, and effective orifice area) were compared to assess the validity of the FSI model. The thrombogenic footprint of the polymeric valve was evaluated using a Lagrangian approach to calculate the stress accumulation (SA) values along multiple platelet trajectories and their statistical distribution. In the commissural regions, platelets were exposed to the highest SA values because of highest stress levels combined with local reverse flow patterns and vortices. Stress-loading waveforms from representative trajectories in regions of interest were emulated in our hemodynamic shearing device (HSD). Platelet activity was measured using our platelet activation state (PAS) assay and the results confirmed the higher thrombogenic potential of the commissural hotspots. In conclusion, the proposed method provides an in depth analysis of the hemodynamic and thrombogenic performance of the polymer valve prototype and identifies locations for further design optimization.

Original languageEnglish (US)
Pages (from-to)3650-3658
Number of pages9
JournalJournal of Biomechanics
Volume48
Issue number13
DOIs
StatePublished - Oct 15 2015

Fingerprint

Fluid structure interaction
Hemodynamics
Platelets
Blood Platelets
Heart Valves
Trajectories
Statistical Distributions
Aortic Diseases
Platelet Activation
Orifices
Prosthetics
Pressure gradient
Aortic Valve
Shearing
Surgical Instruments
Flow patterns
Anticoagulants
Deterioration
Assays
Polymers

Keywords

  • Fluid-structure interaction
  • Hemodynamic prediction
  • Particle tracking analysis
  • Platelet activation
  • Trileaflet polymeric valve

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Rehabilitation
  • Biophysics
  • Biomedical Engineering

Cite this

Hemodynamic and thrombogenic analysis of a trileaflet polymeric valve using a fluid-structure interaction approach. / Piatti, Filippo; Sturla, Francesco; Marom, Gil; Sheriff, Jawaad; Claiborne, Thomas E.; Slepian, Marvin J; Redaelli, Alberto; Bluestein, Danny.

In: Journal of Biomechanics, Vol. 48, No. 13, 15.10.2015, p. 3650-3658.

Research output: Contribution to journalArticle

Piatti, Filippo ; Sturla, Francesco ; Marom, Gil ; Sheriff, Jawaad ; Claiborne, Thomas E. ; Slepian, Marvin J ; Redaelli, Alberto ; Bluestein, Danny. / Hemodynamic and thrombogenic analysis of a trileaflet polymeric valve using a fluid-structure interaction approach. In: Journal of Biomechanics. 2015 ; Vol. 48, No. 13. pp. 3650-3658.
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