Abstract
BACKGROUND AND PURPOSE: The purpose of this study was to identify novel risk factors for intracerebral hemorrhagic stroke (ICH). METHODS: Risk factors were assessed at baseline in a pooled cohort of the Atherosclerosis Risk in Communities Study (ARIC) and the Cardiovascular Health Study (CHS) involving 21 680 adults aged 45 or over. Over 263 489 person-years of follow-up, we identified 135 incident ICH events. RESULTS: In multivariable models, for each SD higher baseline level of fibrinogen, the relative rate of incident ICH increased 35% (95% CI, 17% to 55%). Fibrinogen was more strongly related to ICH in ARIC than in CHS. In multivariable models, those with von Willebrand factor levels above the median were 1.72 (95% CI, 0.97 to 3.03) times more likely to have an incident ICH as those below the median. Factor VIII was significantly positively related to ICH in ARIC (relative rate per standard deviation of 1.31; 95% CI, 1.07 to 1.62), but not in CHS. There was no relation in multivariable models between lipoprotein (a), Factor VII, white blood cell count, or C-reactive protein and ICH. CONCLUSIONS: Greater plasma fibrinogen and, to some degree, von Willebrand factor were associated with increased rates of ICH in these prospective studies, whereas Factor VIII was related to ICH in younger ARIC study participants only.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2268-2273 |
| Number of pages | 6 |
| Journal | Stroke |
| Volume | 39 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1 2008 |
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Keywords
- Cohort studies
- Incidence studies
- Intracerebral hemorrhage
- Risk factors in epidemiology
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Clinical Neurology
- Advanced and Specialized Nursing
- Medicine(all)
Cite this
Hemostatic and inflammatory risk factors for intracerebral hemorrhage in a pooled cohort. / Sturgeon, Jared D.; Folsom, Aaron R.; Longstreth, W. T.; Shahar, Eyal; Rosamond, Wayne D.; Cushman, Mary.
In: Stroke, Vol. 39, No. 8, 01.08.2008, p. 2268-2273.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hemostatic and inflammatory risk factors for intracerebral hemorrhage in a pooled cohort
AU - Sturgeon, Jared D.
AU - Folsom, Aaron R.
AU - Longstreth, W. T.
AU - Shahar, Eyal
AU - Rosamond, Wayne D.
AU - Cushman, Mary
PY - 2008/8/1
Y1 - 2008/8/1
N2 - BACKGROUND AND PURPOSE: The purpose of this study was to identify novel risk factors for intracerebral hemorrhagic stroke (ICH). METHODS: Risk factors were assessed at baseline in a pooled cohort of the Atherosclerosis Risk in Communities Study (ARIC) and the Cardiovascular Health Study (CHS) involving 21 680 adults aged 45 or over. Over 263 489 person-years of follow-up, we identified 135 incident ICH events. RESULTS: In multivariable models, for each SD higher baseline level of fibrinogen, the relative rate of incident ICH increased 35% (95% CI, 17% to 55%). Fibrinogen was more strongly related to ICH in ARIC than in CHS. In multivariable models, those with von Willebrand factor levels above the median were 1.72 (95% CI, 0.97 to 3.03) times more likely to have an incident ICH as those below the median. Factor VIII was significantly positively related to ICH in ARIC (relative rate per standard deviation of 1.31; 95% CI, 1.07 to 1.62), but not in CHS. There was no relation in multivariable models between lipoprotein (a), Factor VII, white blood cell count, or C-reactive protein and ICH. CONCLUSIONS: Greater plasma fibrinogen and, to some degree, von Willebrand factor were associated with increased rates of ICH in these prospective studies, whereas Factor VIII was related to ICH in younger ARIC study participants only.
AB - BACKGROUND AND PURPOSE: The purpose of this study was to identify novel risk factors for intracerebral hemorrhagic stroke (ICH). METHODS: Risk factors were assessed at baseline in a pooled cohort of the Atherosclerosis Risk in Communities Study (ARIC) and the Cardiovascular Health Study (CHS) involving 21 680 adults aged 45 or over. Over 263 489 person-years of follow-up, we identified 135 incident ICH events. RESULTS: In multivariable models, for each SD higher baseline level of fibrinogen, the relative rate of incident ICH increased 35% (95% CI, 17% to 55%). Fibrinogen was more strongly related to ICH in ARIC than in CHS. In multivariable models, those with von Willebrand factor levels above the median were 1.72 (95% CI, 0.97 to 3.03) times more likely to have an incident ICH as those below the median. Factor VIII was significantly positively related to ICH in ARIC (relative rate per standard deviation of 1.31; 95% CI, 1.07 to 1.62), but not in CHS. There was no relation in multivariable models between lipoprotein (a), Factor VII, white blood cell count, or C-reactive protein and ICH. CONCLUSIONS: Greater plasma fibrinogen and, to some degree, von Willebrand factor were associated with increased rates of ICH in these prospective studies, whereas Factor VIII was related to ICH in younger ARIC study participants only.
KW - Cohort studies
KW - Incidence studies
KW - Intracerebral hemorrhage
KW - Risk factors in epidemiology
UR - http://www.scopus.com/inward/record.url?scp=49849102240&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=49849102240&partnerID=8YFLogxK
U2 - 10.1161/STROKEAHA.107.505800
DO - 10.1161/STROKEAHA.107.505800
M3 - Article
VL - 39
SP - 2268
EP - 2273
JO - Stroke
JF - Stroke
SN - 0039-2499
IS - 8
ER -