Hepatic elimination of diazepam

Interactions with albumin, desflurane and sevoflurane

O. Dale, E. J. Frink, L. Thommesen, A Jay Gandolfi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We have studied the effect of sevoflurane and desflurane on the hepatic elimination of diazepam, by incubating slices of rat livers in a closed system. Protein free and protein containing (albumin 10 g litre-1) buffers were used to examine the effect of the anaesthetics on enzyme activity and diazepam binding to albumin. Both anaesthetics (in concentrations of 0.5, 1.5 and 3.0mmol litre-1) reduced the elimination of diazepam slightly in the absence of albumin, while the presence of the protein increased elimination to a maximum of 30% at the greatest concentration of the anaesthetics. These data support previous observations that volatile anaesthetics may interact pharmacokinetically with both liver enzyme activity and drug binding to albumin. (Br. J. Anaesth. 1993; 70: 454-455)

Original languageEnglish (US)
Pages (from-to)454-455
Number of pages2
JournalBritish Journal of Anaesthesia
Volume70
Issue number4
DOIs
StatePublished - Apr 1993

Fingerprint

Anesthetics
diazepam
Diazepam
anesthetics
albumins
Elimination
Albumins
Protein
liver
Liver
Enzyme activity
Enzymes
Volatile Anesthetics
Proteins
Interaction
enzyme activity
Slice
proteins
Buffer
closed loop systems

Keywords

  • Anaesthetics, volatile: desflurane
  • Diazepam
  • Enzyme activity
  • Interactions
  • Isoflurane Biotransformation

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Anesthesiology and Pain Medicine

Cite this

Hepatic elimination of diazepam : Interactions with albumin, desflurane and sevoflurane. / Dale, O.; Frink, E. J.; Thommesen, L.; Gandolfi, A Jay.

In: British Journal of Anaesthesia, Vol. 70, No. 4, 04.1993, p. 454-455.

Research output: Contribution to journalArticle

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