Hepatic metastases: liposomal Gd-DTPA-enhanced MR imaging

Evan C Unger, T. Winokur, P. MacDougall, J. Rosenblum, M. Clair, R. Gatenby, C. Tilcock

Research output: Contribution to journalArticle

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Abstract

Liposomal gadolinium diethylenetriaminepentaacetic acid (DTPA) encapsulated within 70- and 400-nm vesicles was tested as a contrast agent for magnetic resonance (MR) imaging of the liver in rats with hepatic metastases. Liposomal Gd-DTPA caused significant improvement in contrast between liver and tumor (P < .005) on T1-weighted MR images. Smaller 70-nm liposomal Gd-DTPA vesicles caused greater contrast enhancement, reflecting the larger surface-area-to-volume ratio of the smaller vesicles. Liposomal Gd-DTPA-enhanced images permitted significant improvement in metastasis detection by five blinded radiologists (P < .005). By comparison, free Gd-DTPA without liposomes caused a statistically significant reduction in contrast between tumor and liver and reduced lesion detection (P < .01). Liposomal Gd-DTPA also resulted in sustained vascular enhancement for 1 hour after administration. The results suggest that paramagnetic liposomes may become a useful MR imaging contrast agent.

Original languageEnglish (US)
Pages (from-to)81-85
Number of pages5
JournalRadiology
Volume171
Issue number1
StatePublished - 1989
Externally publishedYes

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Magnetic Resonance Imaging
Neoplasm Metastasis
Acids
Liver
Liposomes
Contrast Media
Gadolinium
Blood Vessels
Neoplasms
Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Unger, E. C., Winokur, T., MacDougall, P., Rosenblum, J., Clair, M., Gatenby, R., & Tilcock, C. (1989). Hepatic metastases: liposomal Gd-DTPA-enhanced MR imaging. Radiology, 171(1), 81-85.

Hepatic metastases : liposomal Gd-DTPA-enhanced MR imaging. / Unger, Evan C; Winokur, T.; MacDougall, P.; Rosenblum, J.; Clair, M.; Gatenby, R.; Tilcock, C.

In: Radiology, Vol. 171, No. 1, 1989, p. 81-85.

Research output: Contribution to journalArticle

Unger, EC, Winokur, T, MacDougall, P, Rosenblum, J, Clair, M, Gatenby, R & Tilcock, C 1989, 'Hepatic metastases: liposomal Gd-DTPA-enhanced MR imaging', Radiology, vol. 171, no. 1, pp. 81-85.
Unger EC, Winokur T, MacDougall P, Rosenblum J, Clair M, Gatenby R et al. Hepatic metastases: liposomal Gd-DTPA-enhanced MR imaging. Radiology. 1989;171(1):81-85.
Unger, Evan C ; Winokur, T. ; MacDougall, P. ; Rosenblum, J. ; Clair, M. ; Gatenby, R. ; Tilcock, C. / Hepatic metastases : liposomal Gd-DTPA-enhanced MR imaging. In: Radiology. 1989 ; Vol. 171, No. 1. pp. 81-85.
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