Hepatic protein kinase C: Translocation stimulated by prolactin and partial hepatectomy

Arthur R. Buckley, Charles W. Putnam, Ronald Evans, Hugh E. Laird, Gul N. Shah, David W Montgomery, Diane Haddock Russell

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Prolactin stimulates a hepatotrophic response similar to that caused by phorbol esters or partial hepatectomy in rats. Since phorbol esters, which activate protein kinase C, mimic prolactin action in liver, the relationship between prolactin administration and subsequent hepatic protein kinase C translocation was assessed. Prolactin administration rapidly stimulated a 4-fold elevation of membrane protein kinase C activity. The effect of prolactin on hepatic protein kinase C was specific for lactogenic hormones but could be duplicated by phorbol esters. Further, an increase in serum prolactin was demonstrated subsequent to partial hepatectomy and preceding hepatic protein kinase C translocation. Therefore, translocation of hepatic protein kinase C appears important for hepatic proliferation in response to prolactin administration and to partial hepatectomy.

Original languageEnglish (US)
Pages (from-to)2827-2834
Number of pages8
JournalLife Sciences
Volume41
Issue number26
DOIs
StatePublished - Dec 28 1987

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Hepatectomy
Prolactin
Protein Kinase C
Liver
Phorbol Esters
Rats
Membrane Proteins
Hormones
Serum

ASJC Scopus subject areas

  • Pharmacology

Cite this

Buckley, A. R., Putnam, C. W., Evans, R., Laird, H. E., Shah, G. N., Montgomery, D. W., & Russell, D. H. (1987). Hepatic protein kinase C: Translocation stimulated by prolactin and partial hepatectomy. Life Sciences, 41(26), 2827-2834. https://doi.org/10.1016/0024-3205(87)90429-2

Hepatic protein kinase C : Translocation stimulated by prolactin and partial hepatectomy. / Buckley, Arthur R.; Putnam, Charles W.; Evans, Ronald; Laird, Hugh E.; Shah, Gul N.; Montgomery, David W; Russell, Diane Haddock.

In: Life Sciences, Vol. 41, No. 26, 28.12.1987, p. 2827-2834.

Research output: Contribution to journalArticle

Buckley, AR, Putnam, CW, Evans, R, Laird, HE, Shah, GN, Montgomery, DW & Russell, DH 1987, 'Hepatic protein kinase C: Translocation stimulated by prolactin and partial hepatectomy', Life Sciences, vol. 41, no. 26, pp. 2827-2834. https://doi.org/10.1016/0024-3205(87)90429-2
Buckley, Arthur R. ; Putnam, Charles W. ; Evans, Ronald ; Laird, Hugh E. ; Shah, Gul N. ; Montgomery, David W ; Russell, Diane Haddock. / Hepatic protein kinase C : Translocation stimulated by prolactin and partial hepatectomy. In: Life Sciences. 1987 ; Vol. 41, No. 26. pp. 2827-2834.
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