Hepatitis C virus - Specific CD8+ T cells restricted by donor HLA alleles following liver transplantation

H. R. Rosen, D. J. Hinrichs, R. L. Leistikow, G. Callender, Anne M Wertheimer, M. I. Nishimura, D. M. Lewinsohn, George M. Lauer

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

By necessity, human liver transplantation is performed across HLA barriers. As a result, intracellular infection of the allograft presents a unique immunologic challenge for the recipient's immune system. In this study, we describe the presence of HLA-A2-restricted, hepatitis C virus (HCV)-specific CD8+ T cells in liver transplant recipients in whom the allograft is HLA-A2 positive and the recipient is HLA-A2 negative. These memory-effector T cells are recipient derived and recognize HCV peptide uniquely in the context of HLA-A2. Furthermore, these cells were absent before the transplant, suggesting that the allograft is capable of selectively expanding naive CD8+ T cells. The in vitro specificity to donor HLA allele-restricted CD8+ T cells suggests that these cells may function to control HCV spread in the allograft.

Original languageEnglish (US)
Pages (from-to)848-850
Number of pages3
JournalLiver Transplantation
Volume11
Issue number7
DOIs
StatePublished - Jul 2005
Externally publishedYes

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HLA-A2 Antigen
Hepacivirus
Liver Transplantation
Allografts
Alleles
Tissue Donors
T-Lymphocytes
Immune System
Transplants
Peptides
Liver
Infection

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Rosen, H. R., Hinrichs, D. J., Leistikow, R. L., Callender, G., Wertheimer, A. M., Nishimura, M. I., ... Lauer, G. M. (2005). Hepatitis C virus - Specific CD8+ T cells restricted by donor HLA alleles following liver transplantation. Liver Transplantation, 11(7), 848-850. https://doi.org/10.1002/lt.20423

Hepatitis C virus - Specific CD8+ T cells restricted by donor HLA alleles following liver transplantation. / Rosen, H. R.; Hinrichs, D. J.; Leistikow, R. L.; Callender, G.; Wertheimer, Anne M; Nishimura, M. I.; Lewinsohn, D. M.; Lauer, George M.

In: Liver Transplantation, Vol. 11, No. 7, 07.2005, p. 848-850.

Research output: Contribution to journalArticle

Rosen, HR, Hinrichs, DJ, Leistikow, RL, Callender, G, Wertheimer, AM, Nishimura, MI, Lewinsohn, DM & Lauer, GM 2005, 'Hepatitis C virus - Specific CD8+ T cells restricted by donor HLA alleles following liver transplantation', Liver Transplantation, vol. 11, no. 7, pp. 848-850. https://doi.org/10.1002/lt.20423
Rosen, H. R. ; Hinrichs, D. J. ; Leistikow, R. L. ; Callender, G. ; Wertheimer, Anne M ; Nishimura, M. I. ; Lewinsohn, D. M. ; Lauer, George M. / Hepatitis C virus - Specific CD8+ T cells restricted by donor HLA alleles following liver transplantation. In: Liver Transplantation. 2005 ; Vol. 11, No. 7. pp. 848-850.
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