Hepatopulmonary syndrome

David G. Koch, Michael B. Fallon

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

The hepatopulmonary syndrome (HPS) is a pulmonary complication of cirrhosis and/or portal hypertension whereby patients develop hypoxemia as a result of alterations in pulmonary microvascular tone and architecture. HPS occurs in up to 30% of patients with cirrhosis. Although the degree of hypoxemia does not reliably correlate with the severity of liver disease, patients with HPS have a higher mortality than do patients with cirrhosis without the disorder. There has been progress into defining the mechanisms that lead to hypoxemia in HPS, but to date there are no therapeutic options for HPS aside from liver transplantation.

Original languageEnglish (US)
Pages (from-to)407-420
Number of pages14
JournalClinics in liver disease
Volume18
Issue number2
DOIs
StatePublished - May 2014
Externally publishedYes

Keywords

  • Contrast echocardiography
  • Hepatopulmonary syndrome
  • Hypoxemia
  • Intrapulmonary vasodilatation
  • Liver transplantation
  • Portal hypertension

ASJC Scopus subject areas

  • Hepatology

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