Hereditary risk for cancer

Katherine S. Hunt, Jessica A. Ray, Joanne M Jeter

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cancer prevention consists of understanding cancer incidence in populations, identifying appropriate risk factors for specific cancers, stratifying individuals according to these risk factors, and applying effective interventions to individuals (and sometimes populations) according to their risk status. Evaluation of hereditary risk of cancer is a vital component of risk stratification. Appropriate assessment of hereditary genetic risk can lead to significant changes in the clinical management of individuals who are found to have a hereditary cancer syndrome; conversely, it can identify individuals who are not at elevated risk despite having a strong familial history of cancer. Through cancer risk evaluation, with or without genetic testing for hereditary cancer syndromes, individuals with inherited genetic changes associated with increased predisposition of cancer can be identified prior to the development or diagnosis of cancer. Determining that an individual has a strong inherited predisposition to cancer provides an opportunity to intervene with prevention and screening strategies documented to reduce cancer incidence, morbidity, or mortality.

Original languageEnglish (US)
Title of host publicationFundamentals of Cancer Prevention, Third Edition
PublisherSpringer Berlin Heidelberg
Pages123-150
Number of pages28
ISBN (Print)9783642389832, 9783642389825
DOIs
Publication statusPublished - Jan 1 2014

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hunt, K. S., Ray, J. A., & Jeter, J. M. (2014). Hereditary risk for cancer. In Fundamentals of Cancer Prevention, Third Edition (pp. 123-150). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-38983-2_5