Herpes Simplex Virus Type-1: A Model for Genome Transactions

Paul E Boehmer, Giuseppe Villani

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In many respects, HSV-1 is the prototypic herpes virus. However, HSV-1 also serves as an excellent model system to study genome transactions, including DNA replication, homologous recombination, and the interaction of DNA replication enzymes with DNA damage. Like eukaryotic chromosomes, the HSV-1 genome contains multiple origins of replication. Replication of the HSV-1 genome is mediated by the concerted action of several virus-encoded proteins that are thought to assemble into a multiprotein complex. Several host-encoded factors have also been implicated in viral DNA replication. Furthermore, replication of the HSV-1 genome is known to be closely associated with homologous recombination that, like in many cellular organisms, may function in recombinational repair. Finally, recent data have shed some light on the interaction of essential HSV-1 replication proteins, specifically its DNA polymerase and DNA helicases, with damaged DNA.

Original languageEnglish (US)
Pages (from-to)139-171
Number of pages33
JournalProgress in Nucleic Acid Research and Molecular Biology
Volume75
DOIs
StatePublished - 2003
Externally publishedYes

Fingerprint

Human Herpesvirus 1
Genome
DNA Replication
Homologous Recombination
DNA Helicases
Viruses
Multiprotein Complexes
Replication Origin
Chromosomes, Human, Pair 1
Viral DNA
DNA-Directed DNA Polymerase
DNA Damage
Proteins
DNA
Enzymes

ASJC Scopus subject areas

  • Molecular Biology

Cite this

Herpes Simplex Virus Type-1 : A Model for Genome Transactions. / Boehmer, Paul E; Villani, Giuseppe.

In: Progress in Nucleic Acid Research and Molecular Biology, Vol. 75, 2003, p. 139-171.

Research output: Contribution to journalArticle

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