Heterogeneity of the M1 muscarinic receptor subtype between peripheral lung and cerebral cortex demonstrated by the selective antagonist AF-DX 116

John W. Bloom, Marilyn Halonen, Norma A. Seaver, Henry I. Yamamura

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Recent studies have demonstrated that the majority of muscarinic receptors in rabbit peripheral lung homogenates bind pirenzepine with high affinity (putative M1 subtype). In experiments of AF-DX 116 inhibiting [3H](-)quinuclidinyl benzilate or [3H]pirenzepine, we found similar inhibitory constants for AF-DX 116 binding in rat heart and rabbit peripheral lung that were 4-fold smaller (i.e. of higher affinity) than the inhibitory constant for rat cerebral cortex. This result demonstrate heterogeneity of the M1 muscarinic receptor subtype between peripheral lung and cerebral cortex.

Original languageEnglish (US)
Pages (from-to)491-496
Number of pages6
JournalLife Sciences
Volume41
Issue number4
DOIs
StatePublished - Jul 27 1987

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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