High dry bean intake and reduced risk of advanced colorectal adenoma recurrence among participants in the polyp prevention trial

Elaine Lanza, Terryl J. Hartman, Paul S. Albert, Rusty Shields, Martha Slattery, Bette Caan, Electra Paskett, Frank Iber, James Walter Kikendall, Michael P Lance, Cassandra Daston, Arthur Schatzkin

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Adequate fruit and vegetable intake was suggested to protect against colorectal cancer and colorectal adenomas; however, several recent prospective studies reported no association. We examined the association between fruits and vegetables and adenomatous polyp recurrence in the Polyp Prevention Trial (PPT). The PPT was a low-fat, high-fiber, high-fruit, and vegetable dietary intervention trial of adenoma recurrence, in which there were no differences in the rate of adenoma recurrence in participants in the intervention and control arms of the trial. In this analysis of the entire PPT trial-based cohort, multiple logistic regression analysis was used to estimate the odds ratio (OR) of advanced and nonadvanced adenoma recurrence within quartiles of baseline and change (baseline minus the mean over 3 y) in fruit and vegetable intake, after adjustment for age, total energyy intake, use of nonsteroidal anti-inflammatory drugs, BMI, and gender. There were no significant associations between nonadvanced adenoma recurrence and overall change in fruit and vegetable consumption; however, those in the highest quartile of change in dry bean intake (greatest increase) compared with those in the lowest had a significantly reduced OR for advanced adenoma recurrence (OR = 0.35; 95% CI, 0.18-0.69; P for trend = 0.001). The median in the highest quartile of change in dry bean intake was 370% higher than the baseline intake. The PPT trial-based cohort provides evidence that dry beans may be inversely associated with advanced adenoma recurrence.

Original languageEnglish (US)
Pages (from-to)1896-1903
Number of pages8
JournalJournal of Nutrition
Volume136
Issue number7
StatePublished - 2006

Fingerprint

dry beans
adenoma
Polyps
Adenoma
Vegetables
Recurrence
Fruit
vegetable consumption
fruit consumption
odds ratio
Odds Ratio
vegetables
Adenomatous Polyps
fruits
nonsteroidal anti-inflammatory agents
prospective studies
colorectal neoplasms
Colorectal Neoplasms
Anti-Inflammatory Agents
dietary fiber

Keywords

  • Advanced colorectal adenoma
  • Colorectal adenoma
  • Colorectal cancer
  • Dry beans
  • Fruits and vegetables

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Lanza, E., Hartman, T. J., Albert, P. S., Shields, R., Slattery, M., Caan, B., ... Schatzkin, A. (2006). High dry bean intake and reduced risk of advanced colorectal adenoma recurrence among participants in the polyp prevention trial. Journal of Nutrition, 136(7), 1896-1903.

High dry bean intake and reduced risk of advanced colorectal adenoma recurrence among participants in the polyp prevention trial. / Lanza, Elaine; Hartman, Terryl J.; Albert, Paul S.; Shields, Rusty; Slattery, Martha; Caan, Bette; Paskett, Electra; Iber, Frank; Kikendall, James Walter; Lance, Michael P; Daston, Cassandra; Schatzkin, Arthur.

In: Journal of Nutrition, Vol. 136, No. 7, 2006, p. 1896-1903.

Research output: Contribution to journalArticle

Lanza, E, Hartman, TJ, Albert, PS, Shields, R, Slattery, M, Caan, B, Paskett, E, Iber, F, Kikendall, JW, Lance, MP, Daston, C & Schatzkin, A 2006, 'High dry bean intake and reduced risk of advanced colorectal adenoma recurrence among participants in the polyp prevention trial', Journal of Nutrition, vol. 136, no. 7, pp. 1896-1903.
Lanza, Elaine ; Hartman, Terryl J. ; Albert, Paul S. ; Shields, Rusty ; Slattery, Martha ; Caan, Bette ; Paskett, Electra ; Iber, Frank ; Kikendall, James Walter ; Lance, Michael P ; Daston, Cassandra ; Schatzkin, Arthur. / High dry bean intake and reduced risk of advanced colorectal adenoma recurrence among participants in the polyp prevention trial. In: Journal of Nutrition. 2006 ; Vol. 136, No. 7. pp. 1896-1903.
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