High level expression of fms proto-oncogene mRNA is observed in clinically aggressive human endometrial adenocarcinomas

Barry M. Kacinski, Darryl Carter, Khushbakhat Mittal, Ernest I. Kohorn, R. Shaeffer Bloodgood, John Donahue, Lisa Donofrio, Rob Edwards, Peter E. Schwartz, Joseph T. Chambers, Setsuko K. Chambers

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

Six micron paraffin sections of paraformaldehyde-fixed endometrial currettings of 21 benign and neoplastic endometrial specimens were assayed for tumor cell-specific oncogene expression by in situ hybridization with probes for six oncogenes, beta-actin, and the E. coli plasmid pBR322. In the benign hyperplasias and invasive adenocarcinomas, multiple oncogenes, including erbB, fms, c-myc, and Ki-ras were expressed at significant levels. For the adenocarcinomas, statistical analysis demonstrated that high levels of expression of fms-complementary mRNA correlated strongly with clinicopathologic features (high FIGO histologic grade, high FIGO clinical stage, deep myometrial penetration) predictive of aggressive clinical behavior and poor outcome. The authors discuss the role which M-CSF receptor (the fms gene product) and locally-produced M-CSF may play in the development of the observed aggressively-malignant phenotypes. They also propose that pre-hysterectomy assay of fms gene expression in endometrial currettings in FIGO Stage I patients might be clinically useful to help identify preoperatively those patients with deep myometrial penetration or other locoregional spread.

Original languageEnglish (US)
Pages (from-to)823-829
Number of pages7
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume15
Issue number4
DOIs
StatePublished - Oct 1988
Externally publishedYes

Keywords

  • CSF-1 receptor
  • Endometrial carcinoma
  • FMS oncogene
  • Growth factor receptors
  • In situ hybridization
  • Tumor/stromal interactions

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Fingerprint Dive into the research topics of 'High level expression of fms proto-oncogene mRNA is observed in clinically aggressive human endometrial adenocarcinomas'. Together they form a unique fingerprint.

  • Cite this

    Kacinski, B. M., Carter, D., Mittal, K., Kohorn, E. I., Bloodgood, R. S., Donahue, J., Donofrio, L., Edwards, R., Schwartz, P. E., Chambers, J. T., & Chambers, S. K. (1988). High level expression of fms proto-oncogene mRNA is observed in clinically aggressive human endometrial adenocarcinomas. International Journal of Radiation Oncology, Biology, Physics, 15(4), 823-829. https://doi.org/10.1016/0360-3016(88)90113-7