High levels of Y-chromosome differentiation among native Siberian populations and the genetic signature of a boreal Hunter-Gatherer way of life

Tatiana Karafet, Ludmila P. Osipova, Marina A. Gubina, Olga L. Posukh, Stephen L. Zegura, Michael F Hammer

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

We examined genetic variation on the nonrecombining portion of the Y chromosome (NRY) to investigate the paternal population structure of indigenous Siberian groups and to reconstruct the historical events leading to the peopling of Siberia. A set of 62 biallelic markers on the NRY were genotyped in 1432 males representing 18 Siberian populations, as well as nine populations from Central and East Asia and one from European Russia. A subset of these markers defines the 18 major NRY haplogroups (A-R) recently described by the Y Chromosome Consortium (YCC 2002). While only four of these 18 major NRY haplogroups accounted for ∼95% of Siberian Y-chromosome variation, native Siberian populations differed greatly in their haplogroup composition and exhibited the highest ΦST value for any region of the world. When we divided our Siberian sample into four geographic regions versus five major linguistic groupings, analyses of molecular variance (AMOVA) indicated higher ΦST and ΦCT values for linguistic groups than for geographic groups. Mantel tests also supported the existence of NRY genetic patterns that were correlated with language, indicating that language affiliation might be a better predictor of the genetic affinity among Siberians than their present geographic position. The combined results, including those from a nested cladistic analysis, underscored the important role of directed dispersals, range expansions, and long-distance colonizations bound by common ethnic and linguistic affiliation in shaping the genetic landscape of Siberia. The Siberian pattern of reduced haplogroup diversity within populations combined with high levels of differentiation among populations may be a general feature characteristic of indigenous groups that have small effective population sizes and that have been isolated for long periods of time.

Original languageEnglish (US)
Pages (from-to)761-789
Number of pages29
JournalHuman Biology
Volume74
Issue number6
StatePublished - Dec 2002

Fingerprint

hunter-gatherer
Y Chromosome
Population Genetics
Y chromosome
chromosome
Linguistics
Siberia
Population
effective population size
range expansion
cladistics
Language
population structure
genetic variation
Central Asia
colonization
Far East
Russia
Population Density
East Asia

Keywords

  • Genetic drift
  • Hunter-Gatherers
  • Language families
  • Long distance colonization
  • Siberia
  • Y-chromosome haplogroups

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Genetics
  • Genetics(clinical)
  • Ecology, Evolution, Behavior and Systematics

Cite this

High levels of Y-chromosome differentiation among native Siberian populations and the genetic signature of a boreal Hunter-Gatherer way of life. / Karafet, Tatiana; Osipova, Ludmila P.; Gubina, Marina A.; Posukh, Olga L.; Zegura, Stephen L.; Hammer, Michael F.

In: Human Biology, Vol. 74, No. 6, 12.2002, p. 761-789.

Research output: Contribution to journalArticle

Karafet, Tatiana ; Osipova, Ludmila P. ; Gubina, Marina A. ; Posukh, Olga L. ; Zegura, Stephen L. ; Hammer, Michael F. / High levels of Y-chromosome differentiation among native Siberian populations and the genetic signature of a boreal Hunter-Gatherer way of life. In: Human Biology. 2002 ; Vol. 74, No. 6. pp. 761-789.
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