High performance liquid chromatography of a new anticancer drug, ADCA--physicochemical properties and pharmacokinetics

Peng Yei-Mei Peng, Thomas P. Davis, David S. Alberts

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

We have developed a simple, precise and sensitive high performance liquid chromatographic method for a new anticancer drug, ADCA, in biological samples. The assay has an average recovery of 80 ± 1.6% at physiological concentrations, a precision of <4% and a detection limit of 35 ng/ml plasma. Using this method, ADCA was found to be stable in water, saline, 5% dextrose, and plasma for at least 24 hours at 25°C.

Original languageEnglish (US)
Pages (from-to)361-369
Number of pages9
JournalLife Sciences
Volume29
Issue number4
DOIs
StatePublished - Jul 27 1981

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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