High-resolution optical mapping of the right bundle branch in connexin-40 knockout mice reveals slow conduction

Houman Tamaddon, Dhananjay Vaidya, Alex Simon, David Paul, Jose Jalife, Gregory Morley

Research output: Contribution to journalConference article

Abstract

A study was conducted to characterize the electrophysiological consequences of the null mutation of Cx40 gene (Cx40-/-) on impulse propagation in the specialized conduction system. High-resolution resolution video maps of voltage-dependent fluorescence from the ventricular epicardium and the right bundle (RBB) were obtained using a high-speed CCD camera while simultaneously recording volume conducted ECGs. The data represent the first direct demonstration of conduction defects in the specialized conduction system of Cx40-/-mice.

Original languageEnglish (US)
Pages (from-to)S-53
JournalAnnals of Biomedical Engineering
Volume28
Issue numberSUPPL. 1
StatePublished - Dec 1 2000
Event2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA
Duration: Oct 12 2000Oct 14 2000

ASJC Scopus subject areas

  • Biomedical Engineering

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