High-resolution optical mapping of the right bundle branch in connexin-40 knockout mice reveals slow conduction

Houman Tamaddon, Dhananjay Vaidya, Alex Simon, David Paul, Jose Jalife, Gregory Morley

Research output: Contribution to journalArticle

Abstract

A study was conducted to characterize the electrophysiological consequences of the null mutation of Cx40 gene (Cx40-/-) on impulse propagation in the specialized conduction system. High-resolution resolution video maps of voltage-dependent fluorescence from the ventricular epicardium and the right bundle (RBB) were obtained using a high-speed CCD camera while simultaneously recording volume conducted ECGs. The data represent the first direct demonstration of conduction defects in the specialized conduction system of Cx40-/-mice.

Original languageEnglish (US)
JournalAnnals of Biomedical Engineering
Volume28
Issue numberSUPPL. 1
StatePublished - 2000
Externally publishedYes

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Genes
High speed cameras
CCD cameras
Electrocardiography
Demonstrations
Fluorescence
Defects
Electric potential

ASJC Scopus subject areas

  • Biomedical Engineering

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High-resolution optical mapping of the right bundle branch in connexin-40 knockout mice reveals slow conduction. / Tamaddon, Houman; Vaidya, Dhananjay; Simon, Alex; Paul, David; Jalife, Jose; Morley, Gregory.

In: Annals of Biomedical Engineering, Vol. 28, No. SUPPL. 1, 2000.

Research output: Contribution to journalArticle

Tamaddon, Houman ; Vaidya, Dhananjay ; Simon, Alex ; Paul, David ; Jalife, Jose ; Morley, Gregory. / High-resolution optical mapping of the right bundle branch in connexin-40 knockout mice reveals slow conduction. In: Annals of Biomedical Engineering. 2000 ; Vol. 28, No. SUPPL. 1.
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