High-resolution structure of a virally encoded DNA-translocating conduit and the mechanism of DNA penetration

Lei Sun, Michael G. Rossmann, Bentley A. Fane

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Although ΦX174 DNA pilot protein H is monomeric during procapsid assembly, it forms an oligomeric tube on the host cell surface. Reminiscent of a double-stranded DNA phage tail in form and function, the H tube transports the single-stranded ΦX174 genome across the Escherichia coli cell wall. The 2.4-Å resolution H-tube crystal structure suggests functional and energetic mechanisms that may be common features of DNA transport through virally encoded conduits.

Original languageEnglish (US)
Pages (from-to)10276-10279
Number of pages4
JournalJournal of virology
Volume88
Issue number18
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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