High-risk age window for mortality in children with cystic fibrosis after lung transplantation

Don Hayes, Karen S. McCoy, Bryan A. Whitson, Heidi M. Mansour, Joseph D. Tobias

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

LTx in children with CF remains controversial. The UNOS database was queried from 1987 to 2013 for CF patients <18 yr of age at time of transplant. PCHR model was used to quantify hazard of mortality. 489 recipients were included in the survival analysis. The hazard function of post-transplant mortality was plotted over attained age to identify age window of highest risk, which was 16-20 yr. Unadjusted PCHR model revealed ages immediately after the high-risk window were characterized by lower hazard of mortality (HR = 0.472; 95% CI = 0.302, 0.738; p = 0.001). After adjusting for potential confounders, the decline in mortality hazard immediately after the high-risk window remained statistically significant (HR = 0.394; 95% CI: 0.211, 0.737; p = 0.004). Hazard of mortality in children with CF after LTx was highest between 16 and 20 yr of attained age and declined thereafter.

Original languageEnglish (US)
Pages (from-to)206-210
Number of pages5
JournalPediatric transplantation
Volume19
Issue number2
DOIs
StatePublished - Mar 1 2015

Keywords

  • age
  • allograft failure
  • cystic fibrosis
  • lung transplantation
  • survival

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

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