High specificity in protein recognition by hydrogen-bond-surrogate α-helices

Selective inhibition of the p53/MDM2 complex

Laura K. Henchey, Jason R. Porter, Indraneel Ghosh, Paramjit S. Arora

Research output: Contribution to journalArticle

59 Citations (Scopus)
Original languageEnglish (US)
Pages (from-to)2104-2107
Number of pages4
JournalChemBioChem
Volume11
Issue number15
DOIs
StatePublished - Oct 18 2010

Fingerprint

Proto-Oncogene Proteins c-mdm2
Peptidomimetics
Tumor Suppressor Protein p53
Molecular recognition
X ray crystallography
Hydrogen bonds
Peptides
Proteins
Circular Dichroism
Protein Binding

Keywords

  • Helical structures
  • Inhibitors
  • Molecular recognition
  • Peptidomimetics
  • Protein-protein interactions

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology

Cite this

High specificity in protein recognition by hydrogen-bond-surrogate α-helices : Selective inhibition of the p53/MDM2 complex. / Henchey, Laura K.; Porter, Jason R.; Ghosh, Indraneel; Arora, Paramjit S.

In: ChemBioChem, Vol. 11, No. 15, 18.10.2010, p. 2104-2107.

Research output: Contribution to journalArticle

Henchey, Laura K. ; Porter, Jason R. ; Ghosh, Indraneel ; Arora, Paramjit S. / High specificity in protein recognition by hydrogen-bond-surrogate α-helices : Selective inhibition of the p53/MDM2 complex. In: ChemBioChem. 2010 ; Vol. 11, No. 15. pp. 2104-2107.
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