High-transmission-efficiency and side-viewing micro OIDRS probe for fast and minimally invasive tumor margin detection

Alejandro Garcia-Uribe, Cheng Chung Chang, Murat Kaya Yapici, Jun Zou, Bhaskar Banerjee, John Kuczynski, Evan S. Ong, Erin S. Marner, Lihong V. Wang

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The determination of a cancer free margin I organ is a difficult and time consuming process, with an unmet need for rapid determination of tumor margin at surgery. In this paper, we report the design, fabrication, and testing of a novel miniaturized optical sensor probe with "side-viewing" capability. Its unprecedented small size, unique "side-viewing" capability, and high optical transmission efficiency enable the agile maneuvering and efficient data collection even in the narrow cavities inside the human body. The sensor probe consists of four micromachined substrates with optical fibers for oblique light incidence and collection of spatially resolved diffuse reflectance from the contacted tissues. The optical sensor probe has been used to conduct the oblique incidence diffuse reflectance spectroscopy (OIDRS) on a human pancreatic specimen. Based on the measurement results, the margin of the malignant tumor has been successfully determined optically, which matches well with the histological results.

Original languageEnglish (US)
Article number5585661
Pages (from-to)891-896
Number of pages6
JournalIEEE Sensors Journal
Volume11
Issue number4
DOIs
StatePublished - 2011

Keywords

  • Diffuse reflectance
  • microoptical probe
  • oblique incidence
  • pancreatic cancer
  • spectroscopy
  • tumor margin

ASJC Scopus subject areas

  • Instrumentation
  • Electrical and Electronic Engineering

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