High viremia is associated with high levels of in vivo major histocompatibility complex class I downregulation in rhesus macaques infected with simian immunodeficiency virus SIVmac239

Thomas C. Friedrich, Shari M. Piaskowski, Enrique J. León, Jessica R. Furlott, Nicholas J. Maness, Kimberly L. Weisgrau, Caitlin E. Mac Nair, Andrea M. Weiler, John T. Loffredo, Matthew R. Reynolds, K. Y. Williams, Yann C. Klimentidis, Nancy A. Wilson, David B. Allison, Eva G. Rakasz

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Human and simian immunodeficiency viruses (HIV and SIV) downregulate major histocompatibility complex class I (MHC-I) molecules from the surface of infected cells. Although this activity is conserved across viral isolates, its importance in AIDS pathogenesis is not clear. We therefore developed an assay to detect the level of MHC-I expression of SIV-infected cells directly ex vivo. Here we show that the extent of MHC-I downregulation is greatest in SIVmac239-infected macaques that never effectively control virus replication. Our results suggest that a high level of MHC-I downregulation is a hallmark of fast disease progression in SIV infection.

Original languageEnglish (US)
Pages (from-to)5443-5447
Number of pages5
JournalJournal of virology
Volume84
Issue number10
DOIs
StatePublished - May 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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    Friedrich, T. C., Piaskowski, S. M., León, E. J., Furlott, J. R., Maness, N. J., Weisgrau, K. L., Mac Nair, C. E., Weiler, A. M., Loffredo, J. T., Reynolds, M. R., Williams, K. Y., Klimentidis, Y. C., Wilson, N. A., Allison, D. B., & Rakasz, E. G. (2010). High viremia is associated with high levels of in vivo major histocompatibility complex class I downregulation in rhesus macaques infected with simian immunodeficiency virus SIVmac239. Journal of virology, 84(10), 5443-5447. https://doi.org/10.1128/JVI.02452-09