Highly enantio- and diastereoselective organocatalytic cascade aza-Michael-Michael reactions: A direct method for the synthesis of trisubstituted chiral pyrrolidines

Hao Li, Liansuo Zu, Hexin Xie, Jian Wang, Wei Wang

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

An unprecedented highly enantio- and diastereoselective cascade aza-Michael-Michael reaction of α,β-unsaturated aldehydes with trans-γ-Ts protected amino α,β-unsaturated ester has been developed; the simple and practical process, efficiently catalyzed by chiral diphenylprolinol TMS ether, serves as a powerful access to highly functionalized trisubstituted chiral pyrrolidines.

Original languageEnglish (US)
Pages (from-to)5636-5638
Number of pages3
JournalChemical Communications
Issue number43
DOIs
StatePublished - 2008
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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