Highly enantioselective conjugate addition of nitroalkanes to enones catalyzed by cinchona alkaloid derived primary amine

Wenjing Liu, Desheng Mei, Wei Wang, Wenhu Duan

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

A cinchona alkaloid derived primary amine catalyzed conjugate addition of nitroalkanes to enones is described. The process affords the Michael adducts in good yield and with up to 99% ee for both acyclic and cyclic enones.

Original languageEnglish (US)
Pages (from-to)3791-3793
Number of pages3
JournalTetrahedron Letters
Volume54
Issue number29
DOIs
StatePublished - Jul 17 2013
Externally publishedYes

Keywords

  • Asymmetric conjugate addition
  • Chiral primary amine catalysis
  • Cinchona alkaloids
  • Enones
  • Nitroalkanes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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