A cinchona alkaloid derived primary amine catalyzed conjugate addition of nitroalkanes to enones is described. The process affords the Michael adducts in good yield and with up to 99% ee for both acyclic and cyclic enones.
- Asymmetric conjugate addition
- Chiral primary amine catalysis
- Cinchona alkaloids
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry