Highly stereoselective reductions of α-alkoxy-β-keto esters. Aspects of the mechanism of sodium borohydride reduction of ketones in 2-propanol

Richard S. Glass, Donald R. Deardorff, Kevin Henegar

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Reduction of α-alkoxy-β-keto esters with sodium borohydride in 2-propanol proceeds with high stereoselectivity via a five-membered ring chelated sodium ion.

Original languageEnglish (US)
Pages (from-to)2467-2470
Number of pages4
JournalTetrahedron Letters
Volume21
Issue number26
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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