High‐pressure liquid chromatographic analysis of melphalan in plasma

S. Y. Chang, D. S. Alberts, L. R. Melnick, P. D. Walson, S. E. Salmon

Research output: Contribution to journalArticlepeer-review

79 Scopus citations

Abstract

A new sensitive and rapid high‐pressure liquid chromatographic determination of melphalan in plasma was developed. Recovery of 1 μg added to 1 ml of plasma at 23° was 94% but was greatly reduced at higher temperature. The method has been applied to plasma determinations of melphalan in rats and humans and is currently being utilized for human pharmacokinetic studies.

Original languageEnglish (US)
Pages (from-to)679-682
Number of pages4
JournalJournal of pharmaceutical sciences
Volume67
Issue number5
DOIs
StatePublished - May 1978

Keywords

  • Antineoplastic agents—melphalan, high‐pressure liquid chromatographic analysis in plasma
  • High‐pressure liquid chromatography—analysis, melphalan in plasma
  • Melphalan—high‐pressure liquid chromatographic analysis in plasma

ASJC Scopus subject areas

  • Pharmaceutical Science

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