Hip geometry in diabetic women: Implications for fracture risk

Rajesh Garg, Zhao Chen, Thomas Beck, Jane A. Cauley, Guanglin Wu, Dorothy Nelson, Beth Lewis, Andrea Lacroix, Meryl S. Leboff

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: Women with type 2 diabetes mellitus (T2DM) have a higher risk of fractures despite increased bone mineral density (BMD) as compared to women without diabetes. We hypothesized that bone strength is diminished in women with T2DM after accounting for lean body mass, which may contribute to their increased fracture risk. Methods: Participants from Women's Health Initiative Observational Study were included in this cross-sectional study. These analyses include 3 groups of women: 1) T2DM women on diet or oral hypoglycemic agents (n = 299); 2) T2DM women on insulin therapy (with or without oral agents) (n = 128); and 3) Non-diabetic control women (n = 5497). Hip structural analyses were done using the validated Beck's method on hip scans from dual energy x-ray absorptiometry (DXA). We compared BMD and section modulus (bending strength) at the narrow neck with and without correcting for total body DXA lean body mass. Results: Women in all three groups were of similar ages (63.7, 64.6 and 64.2 years, respectively) and heights, but those with T2DM were heavier, with greater lean body weight vs controls (P <.001). In both diabetic groups, absolute BMD and section modulus were higher compared with controls. However, after adjusting for total lean body weight, diabetic women on insulin had significantly lower BMD and section modulus. Conclusion: Adjusted for lean body weight, the BMD and bending strength in the femoral neck are significantly lower in insulin-treated diabetic women vs controls. This may represent altered adaptation of bone modeling and explain the higher fracture risk in patients with T2DM.

Original languageEnglish (US)
Pages (from-to)1756-1762
Number of pages7
JournalMetabolism: Clinical and Experimental
Volume61
Issue number12
DOIs
StatePublished - Dec 2012

Fingerprint

Hip
Type 2 Diabetes Mellitus
Bone Density
Body Weight
Insulin
X-Rays
Bone and Bones
Femur Neck
Women's Health
Hypoglycemic Agents
Observational Studies
Neck
Cross-Sectional Studies
Diet

Keywords

  • Bone Geometry
  • Diabetes mellitus
  • Hip structural analysis
  • Women's Health Initiative Study

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Garg, R., Chen, Z., Beck, T., Cauley, J. A., Wu, G., Nelson, D., ... Leboff, M. S. (2012). Hip geometry in diabetic women: Implications for fracture risk. Metabolism: Clinical and Experimental, 61(12), 1756-1762. https://doi.org/10.1016/j.metabol.2012.05.010

Hip geometry in diabetic women : Implications for fracture risk. / Garg, Rajesh; Chen, Zhao; Beck, Thomas; Cauley, Jane A.; Wu, Guanglin; Nelson, Dorothy; Lewis, Beth; Lacroix, Andrea; Leboff, Meryl S.

In: Metabolism: Clinical and Experimental, Vol. 61, No. 12, 12.2012, p. 1756-1762.

Research output: Contribution to journalArticle

Garg, R, Chen, Z, Beck, T, Cauley, JA, Wu, G, Nelson, D, Lewis, B, Lacroix, A & Leboff, MS 2012, 'Hip geometry in diabetic women: Implications for fracture risk', Metabolism: Clinical and Experimental, vol. 61, no. 12, pp. 1756-1762. https://doi.org/10.1016/j.metabol.2012.05.010
Garg, Rajesh ; Chen, Zhao ; Beck, Thomas ; Cauley, Jane A. ; Wu, Guanglin ; Nelson, Dorothy ; Lewis, Beth ; Lacroix, Andrea ; Leboff, Meryl S. / Hip geometry in diabetic women : Implications for fracture risk. In: Metabolism: Clinical and Experimental. 2012 ; Vol. 61, No. 12. pp. 1756-1762.
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