Hippocampal glycogen metabolism, EEG, and behavior

A. Uecker, C. A. Barnes, B. L. McNaughton, E. M. Reiman

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Glycogen phosphorylase a (GPa) is correlated with metabolic activation, suggesting its potential use as a marker for neuronal activity. In dentate gyrus, GPa patches are induced by glutamate infusion. Hippocampal electroencephalogram (EEG) and neuronal firing tales are modulated by behavioral state, anti cell discharge is suppressed by restraint. In rats, under conditions of free exploration, passive movement under loose or secure restraint, quiet wakefulness, and anesthesia, GPa activity and 6-10-Hz theta power were inversely related: The more active the animal, the stronger the theta rhythm and the lower the GPa activity. Thus, GPa was feast under conditions in which the hippocampus processes external information, and at intermediate levels during restraint when neuronal firing is lowest. This dissociation raises doubts about the use of metabolic activity as an indicator of changes in neuronal activity or of information processing per se.

Original languageEnglish (US)
Pages (from-to)283-291
Number of pages9
JournalBehavioral Neuroscience
Volume111
Issue number2
DOIs
StatePublished - Apr 1 1997

ASJC Scopus subject areas

  • Behavioral Neuroscience

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