TY - JOUR
T1 - Hippocampal glycogen metabolism, EEG, and behavior
AU - Uecker, A.
AU - Barnes, C. A.
AU - McNaughton, B. L.
AU - Reiman, E. M.
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1997/4
Y1 - 1997/4
N2 - Glycogen phosphorylase a (GPa) is correlated with metabolic activation, suggesting its potential use as a marker for neuronal activity. In dentate gyrus, GPa patches are induced by glutamate infusion. Hippocampal electroencephalogram (EEG) and neuronal firing tales are modulated by behavioral state, anti cell discharge is suppressed by restraint. In rats, under conditions of free exploration, passive movement under loose or secure restraint, quiet wakefulness, and anesthesia, GPa activity and 6-10-Hz theta power were inversely related: The more active the animal, the stronger the theta rhythm and the lower the GPa activity. Thus, GPa was feast under conditions in which the hippocampus processes external information, and at intermediate levels during restraint when neuronal firing is lowest. This dissociation raises doubts about the use of metabolic activity as an indicator of changes in neuronal activity or of information processing per se.
AB - Glycogen phosphorylase a (GPa) is correlated with metabolic activation, suggesting its potential use as a marker for neuronal activity. In dentate gyrus, GPa patches are induced by glutamate infusion. Hippocampal electroencephalogram (EEG) and neuronal firing tales are modulated by behavioral state, anti cell discharge is suppressed by restraint. In rats, under conditions of free exploration, passive movement under loose or secure restraint, quiet wakefulness, and anesthesia, GPa activity and 6-10-Hz theta power were inversely related: The more active the animal, the stronger the theta rhythm and the lower the GPa activity. Thus, GPa was feast under conditions in which the hippocampus processes external information, and at intermediate levels during restraint when neuronal firing is lowest. This dissociation raises doubts about the use of metabolic activity as an indicator of changes in neuronal activity or of information processing per se.
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U2 - 10.1037/0735-7044.111.2.283
DO - 10.1037/0735-7044.111.2.283
M3 - Article
C2 - 9106669
AN - SCOPUS:0030992366
VL - 111
SP - 283
EP - 291
JO - Behavioral Neuroscience
JF - Behavioral Neuroscience
SN - 0735-7044
IS - 2
ER -