Hippocampal granule cells in normal aging: insights from electrophysiological and functional imaging experiments

Monica K. Chawla, Carol A. Barnes

Research output: Chapter in Book/Report/Conference proceedingChapter

19 Scopus citations

Abstract

Normal aging, in the absence of neurodegenerative disease, can provide important insights into the mechanisms by which the brain can maintain cognitive abilities across the lifespan. Hippocampal-dependent memory processes can become vulnerable as age advances. The focus of this chapter is the contribution of hippocampal granule cells to cognitive impairments that are observed during aging. A number of alterations in structure, function, and gene expression have been observed in aged granule cells, any of which may lead to adaptive, compensatory or detrimental consequences to hippocampal function. As the average life span of humans continues to increase, those who reach 100 years or beyond is more common. Individuals that have aged successfully, and exhibit high levels of cognitive ability can provide useful clues into the enormous potential possessed by the mammalian brain.

Original languageEnglish (US)
Title of host publicationThe Dentate Gyrus
Subtitle of host publicationA Comprehensive Guide to Structure, Function, and Clinical Implications
PublisherElsevier
Pages661-678,819-821
ISBN (Print)0444530150, 9780444530158
DOIs
StatePublished - Jan 1 2007

Publication series

NameProgress in Brain Research
Volume163
ISSN (Print)0079-6123

Keywords

  • dentate gyrus
  • fascia dentata
  • fluorescence in situ hybridization
  • FMRI
  • LTP

ASJC Scopus subject areas

  • Neuroscience(all)

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    Chawla, M. K., & Barnes, C. A. (2007). Hippocampal granule cells in normal aging: insights from electrophysiological and functional imaging experiments. In The Dentate Gyrus: A Comprehensive Guide to Structure, Function, and Clinical Implications (pp. 661-678,819-821). (Progress in Brain Research; Vol. 163). Elsevier. https://doi.org/10.1016/S0079-6123(07)63036-2