Hippocampal Synaptic Enhancement as a Basis for Learning and Memory: A Selected Review of Current Evidence from Behaving Animals

Carol A Barnes, C. A. Erickson, S. Davis, B. L. McNaughton

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Since the discovery of long-term synaptic enhancement and long-term potentiation (LTE/LTP), a substantial body of empirical support has accumulated for the theory that LTP of hippocampal synapses represents the experimental activation of processes that normally subserve distributed information storage. Although most experiments have yielded data that tend to support this hypothesis, recently some of this evidence has been called into question. This chapter examines the current status of the suggestion that a process based on LTP underlies information storage. In addition to electrically induced LTP, another form of synaptic strengthening can be induced through behavioral means at some hippocampal synapses. The extent to which this latter process (short-term exploratory modulation) may reflect information acquisition by the hippocampus is also discussed.

Original languageEnglish (US)
Title of host publicationBrain and Memory: Modulation and Mediation of Neuroplasticity
PublisherOxford University Press
ISBN (Print)9780199847877, 9780195082944
DOIs
StatePublished - Mar 22 2012

Fingerprint

Information Storage and Retrieval
Synapses
Learning
Long-Term Potentiation
Hippocampus

Keywords

  • Hippocampus
  • Information storage
  • Long-term potentiation
  • Long-term synaptic enhancement
  • Shortterm exploratory modulation
  • Synapses

ASJC Scopus subject areas

  • Psychology(all)

Cite this

Barnes, C. A., Erickson, C. A., Davis, S., & McNaughton, B. L. (2012). Hippocampal Synaptic Enhancement as a Basis for Learning and Memory: A Selected Review of Current Evidence from Behaving Animals. In Brain and Memory: Modulation and Mediation of Neuroplasticity Oxford University Press. https://doi.org/10.1093/acprof:oso/9780195082944.003.0016

Hippocampal Synaptic Enhancement as a Basis for Learning and Memory : A Selected Review of Current Evidence from Behaving Animals. / Barnes, Carol A; Erickson, C. A.; Davis, S.; McNaughton, B. L.

Brain and Memory: Modulation and Mediation of Neuroplasticity. Oxford University Press, 2012.

Research output: Chapter in Book/Report/Conference proceedingChapter

Barnes, CA, Erickson, CA, Davis, S & McNaughton, BL 2012, Hippocampal Synaptic Enhancement as a Basis for Learning and Memory: A Selected Review of Current Evidence from Behaving Animals. in Brain and Memory: Modulation and Mediation of Neuroplasticity. Oxford University Press. https://doi.org/10.1093/acprof:oso/9780195082944.003.0016
Barnes CA, Erickson CA, Davis S, McNaughton BL. Hippocampal Synaptic Enhancement as a Basis for Learning and Memory: A Selected Review of Current Evidence from Behaving Animals. In Brain and Memory: Modulation and Mediation of Neuroplasticity. Oxford University Press. 2012 https://doi.org/10.1093/acprof:oso/9780195082944.003.0016
Barnes, Carol A ; Erickson, C. A. ; Davis, S. ; McNaughton, B. L. / Hippocampal Synaptic Enhancement as a Basis for Learning and Memory : A Selected Review of Current Evidence from Behaving Animals. Brain and Memory: Modulation and Mediation of Neuroplasticity. Oxford University Press, 2012.
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