Hippocampal Synaptic Enhancement as a Basis for Learning and Memory: A Selected Review of Current Evidence from Behaving Animals

C. A. Barnes, C. A. Erickson, S. Davis, B. L. McNaughton

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Since the discovery of long-term synaptic enhancement and long-term potentiation (LTE/LTP), a substantial body of empirical support has accumulated for the theory that LTP of hippocampal synapses represents the experimental activation of processes that normally subserve distributed information storage. Although most experiments have yielded data that tend to support this hypothesis, recently some of this evidence has been called into question. This chapter examines the current status of the suggestion that a process based on LTP underlies information storage. In addition to electrically induced LTP, another form of synaptic strengthening can be induced through behavioral means at some hippocampal synapses. The extent to which this latter process (short-term exploratory modulation) may reflect information acquisition by the hippocampus is also discussed.

Original languageEnglish (US)
Title of host publicationBrain and Memory
Subtitle of host publicationModulation and Mediation of Neuroplasticity
PublisherOxford University Press
ISBN (Electronic)9780199847877
ISBN (Print)9780195082944
DOIs
StatePublished - Mar 22 2012

Keywords

  • Hippocampus
  • Information storage
  • Long-term potentiation
  • Long-term synaptic enhancement
  • Shortterm exploratory modulation
  • Synapses

ASJC Scopus subject areas

  • Psychology(all)

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    Barnes, C. A., Erickson, C. A., Davis, S., & McNaughton, B. L. (2012). Hippocampal Synaptic Enhancement as a Basis for Learning and Memory: A Selected Review of Current Evidence from Behaving Animals. In Brain and Memory: Modulation and Mediation of Neuroplasticity Oxford University Press. https://doi.org/10.1093/acprof:oso/9780195082944.003.0016