Abstract
Since the discovery of long-term synaptic enhancement and long-term potentiation (LTE/LTP), a substantial body of empirical support has accumulated for the theory that LTP of hippocampal synapses represents the experimental activation of processes that normally subserve distributed information storage. Although most experiments have yielded data that tend to support this hypothesis, recently some of this evidence has been called into question. This chapter examines the current status of the suggestion that a process based on LTP underlies information storage. In addition to electrically induced LTP, another form of synaptic strengthening can be induced through behavioral means at some hippocampal synapses. The extent to which this latter process (short-term exploratory modulation) may reflect information acquisition by the hippocampus is also discussed.
| Original language | English (US) |
|---|---|
| Title of host publication | Brain and Memory: Modulation and Mediation of Neuroplasticity |
| Publisher | Oxford University Press |
| ISBN (Print) | 9780199847877, 9780195082944 |
| DOIs | |
| State | Published - Mar 22 2012 |
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Keywords
- Hippocampus
- Information storage
- Long-term potentiation
- Long-term synaptic enhancement
- Shortterm exploratory modulation
- Synapses
ASJC Scopus subject areas
- Psychology(all)
Cite this
Hippocampal Synaptic Enhancement as a Basis for Learning and Memory : A Selected Review of Current Evidence from Behaving Animals. / Barnes, Carol A; Erickson, C. A.; Davis, S.; McNaughton, B. L.
Brain and Memory: Modulation and Mediation of Neuroplasticity. Oxford University Press, 2012.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Hippocampal Synaptic Enhancement as a Basis for Learning and Memory
T2 - A Selected Review of Current Evidence from Behaving Animals
AU - Barnes, Carol A
AU - Erickson, C. A.
AU - Davis, S.
AU - McNaughton, B. L.
PY - 2012/3/22
Y1 - 2012/3/22
N2 - Since the discovery of long-term synaptic enhancement and long-term potentiation (LTE/LTP), a substantial body of empirical support has accumulated for the theory that LTP of hippocampal synapses represents the experimental activation of processes that normally subserve distributed information storage. Although most experiments have yielded data that tend to support this hypothesis, recently some of this evidence has been called into question. This chapter examines the current status of the suggestion that a process based on LTP underlies information storage. In addition to electrically induced LTP, another form of synaptic strengthening can be induced through behavioral means at some hippocampal synapses. The extent to which this latter process (short-term exploratory modulation) may reflect information acquisition by the hippocampus is also discussed.
AB - Since the discovery of long-term synaptic enhancement and long-term potentiation (LTE/LTP), a substantial body of empirical support has accumulated for the theory that LTP of hippocampal synapses represents the experimental activation of processes that normally subserve distributed information storage. Although most experiments have yielded data that tend to support this hypothesis, recently some of this evidence has been called into question. This chapter examines the current status of the suggestion that a process based on LTP underlies information storage. In addition to electrically induced LTP, another form of synaptic strengthening can be induced through behavioral means at some hippocampal synapses. The extent to which this latter process (short-term exploratory modulation) may reflect information acquisition by the hippocampus is also discussed.
KW - Hippocampus
KW - Information storage
KW - Long-term potentiation
KW - Long-term synaptic enhancement
KW - Shortterm exploratory modulation
KW - Synapses
UR - http://www.scopus.com/inward/record.url?scp=84939818089&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84939818089&partnerID=8YFLogxK
U2 - 10.1093/acprof:oso/9780195082944.003.0016
DO - 10.1093/acprof:oso/9780195082944.003.0016
M3 - Chapter
AN - SCOPUS:84939818089
SN - 9780199847877
SN - 9780195082944
BT - Brain and Memory: Modulation and Mediation of Neuroplasticity
PB - Oxford University Press
ER -