Hippocampal volume is preserved and fails to predict recognition memory impairment in aged rhesus monkeys (Macaca mulatta)

Jul Lea T Shamy, Michael H. Buonocore, Leah M. Makaron, David G. Amaral, Carol A Barnes, Peter R. Rapp

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Aged monkeys exhibit deficits in memory mediated by the medial temporal lobe system, similar to the effects of normal aging in humans. The contribution of structural deterioration to age-associated memory loss was explored using magnetic resonance imaging techniques. We quantified hippocampal, cerebral and ventricular volumes in young (n = 6, 9-12 years) and aged (n = 6, 24-29 years) rhesus monkeys. Eleven subjects were tested on a recognition memory task, delayed non-matching-to-sample (DNMS). Compared to young animals, aged monkeys exhibited robust learning deficits and significant memory impairments when challenged with longer retention intervals. Hippocampal volume was statistically equivalent across age groups, differing by less than 6%, and there was no correlation between this measure and DNMS performance. Variability in cerebral volume was greater in the aged compared to young monkeys and this parameter was marginally correlated with DNMS performance with a 10-min delay. These findings confirm and extend the conclusion of recent post-mortem histological analyses demonstrating that normal cognitive aging occurs independently of gross structural deterioration in the primate hippocampus.

Original languageEnglish (US)
Pages (from-to)1405-1415
Number of pages11
JournalNeurobiology of Aging
Volume27
Issue number10
DOIs
StatePublished - Oct 2006

Fingerprint

Memory Disorders
Macaca mulatta
Haplorhini
Repression (Psychology)
Temporal Lobe
Primates
Hippocampus
Age Groups
Magnetic Resonance Imaging
Learning
Recognition (Psychology)

Keywords

  • Aging
  • Cognitive decline
  • DNMS
  • Medial temporal lobe
  • MRI

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Hippocampal volume is preserved and fails to predict recognition memory impairment in aged rhesus monkeys (Macaca mulatta). / Shamy, Jul Lea T; Buonocore, Michael H.; Makaron, Leah M.; Amaral, David G.; Barnes, Carol A; Rapp, Peter R.

In: Neurobiology of Aging, Vol. 27, No. 10, 10.2006, p. 1405-1415.

Research output: Contribution to journalArticle

Shamy, Jul Lea T ; Buonocore, Michael H. ; Makaron, Leah M. ; Amaral, David G. ; Barnes, Carol A ; Rapp, Peter R. / Hippocampal volume is preserved and fails to predict recognition memory impairment in aged rhesus monkeys (Macaca mulatta). In: Neurobiology of Aging. 2006 ; Vol. 27, No. 10. pp. 1405-1415.
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