Histamine and slow reacting substance in acid-induced pneumonitis.

R. C. Bone, S. Lerner, D. Stetschulte, E. Murphy, J. Wolfe, Richard E Sobonya

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Acid pneumonitis was produced in 18 dogs by the tracheal instillation of 3 ml/kg 0.1 N hydrochloric acid. Arterial and mixed venous oxygen tension, static compliance and pulmonary capillary wedge pressure were measured during a 2-hour observation period. Plasma histamine (measured by the enzymatic isotopic assay) increased from 1.7 +/- 0.2 ng/ml (mean +/- SE) before acid injury to 13.5 +/- 1.9 ng/ml after injury (p less than 0.05). In one group of 7 control dogs, 3 ml/kg of normal saline produced no increase in plasma histamine. Pulmonary edema secretions from acid injured animals had a histamine level of 30.3 +/- 3.8 ng/ml and slow reacting substance was detected in 7 of 11 animals. The slow reacting substance was an antihistamine-resistant, ethanol extractable substance that contracted guinea pig ileum. Lung weight-body weight ratio PaO2, and static compliance were different with acid pneumonitis compared to controls. Total protein was not different in the tracheal secretions compared to plasma. We conclude that histamine and slow reacting substance are released in this animal model of acid pneumonitis and may be important in the pathogenesis of the lung injury.

Original languageEnglish (US)
Pages (from-to)365-377
Number of pages13
JournalMicrocirculation, endothelium, and lymphatics
Volume1
Issue number3
StatePublished - Jun 1984
Externally publishedYes

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Autacoids
Histamine
Pneumonia
Acids
Compliance
Dogs
Pulmonary Wedge Pressure
Hydrochloric Acid
Histamine Antagonists
Wounds and Injuries
Enzyme Assays
Lung Injury
Pulmonary Edema
Ileum
Guinea Pigs
Ethanol
Animal Models
Body Weight
Observation
Oxygen

ASJC Scopus subject areas

  • Pharmacology

Cite this

Bone, R. C., Lerner, S., Stetschulte, D., Murphy, E., Wolfe, J., & Sobonya, R. E. (1984). Histamine and slow reacting substance in acid-induced pneumonitis. Microcirculation, endothelium, and lymphatics, 1(3), 365-377.

Histamine and slow reacting substance in acid-induced pneumonitis. / Bone, R. C.; Lerner, S.; Stetschulte, D.; Murphy, E.; Wolfe, J.; Sobonya, Richard E.

In: Microcirculation, endothelium, and lymphatics, Vol. 1, No. 3, 06.1984, p. 365-377.

Research output: Contribution to journalArticle

Bone, RC, Lerner, S, Stetschulte, D, Murphy, E, Wolfe, J & Sobonya, RE 1984, 'Histamine and slow reacting substance in acid-induced pneumonitis.', Microcirculation, endothelium, and lymphatics, vol. 1, no. 3, pp. 365-377.
Bone, R. C. ; Lerner, S. ; Stetschulte, D. ; Murphy, E. ; Wolfe, J. ; Sobonya, Richard E. / Histamine and slow reacting substance in acid-induced pneumonitis. In: Microcirculation, endothelium, and lymphatics. 1984 ; Vol. 1, No. 3. pp. 365-377.
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