Histamine-immunoreactive local neurons in the antennal lobes of the hymenoptera

Andrew M. Dacks, Carolina E. Reisenman, Angelique C. Paulk, Alan J Nighorn

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Neural networks receive input that is transformed before being sent as output to higher centers of processing. These transformations are often mediated by local interneurons (LNs) that influence output based on activity across the network. In primary olfactory centers, the LNs that mediate these lateral interactions are extremely diverse. For instance, the antennal lobes (ALs) of bumblebees possess both γ-aminobutyric acid (GABA)-and histamine-immunoreactive (HA-ir) LNs, and both are neurotransmitters associated with fast forms of inhibition. Although the GABAergic network of the AL has been extensively studied, we sought to examine the anatomical features of the HA-ir LNs in relation to the other cellular elements of the bumblebee AL. As a population, HA-ir LNs densely innervate the glomerular core and sparsely arborize in the outer glomerular rind, overlapping with the terminals of olfactory receptor neurons. Individual fills of HA-ir LNs revealed heavy arborization of the outer ring of a single "principal" glomerulus and sparse arborization in the core of other glomeruli. In contrast, projection neurons and GABA-immunoreactive LNs project throughout the glomerular volume. To provide insight into the selective pressures that resulted in the evolution of HA-ir LNs, we determined the phylogenetic distribution of HA-ir LNs in the AL. HA-ir LNs were present in all but the most basal hymenopteran examined, although there were significant morphological differences between major groups within the Hymenoptera. The ALs of other insect taxa examined lacked HA-ir LNs, suggesting that this population of LNs arose within the Hymenoptera and underwent extensive morphological modification.

Original languageEnglish (US)
Pages (from-to)2917-2933
Number of pages17
JournalJournal of Comparative Neurology
Volume518
Issue number15
DOIs
StatePublished - Aug 1 2010

Fingerprint

Hymenoptera
Interneurons
Histamine
Neurons
Olfactory Receptor Neurons
Aminobutyrates
GABAergic Neurons
gamma-Aminobutyric Acid
Population
Neurotransmitter Agents
Insects

Keywords

  • histamine
  • Hymenoptera
  • insect brain
  • olfaction

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Histamine-immunoreactive local neurons in the antennal lobes of the hymenoptera. / Dacks, Andrew M.; Reisenman, Carolina E.; Paulk, Angelique C.; Nighorn, Alan J.

In: Journal of Comparative Neurology, Vol. 518, No. 15, 01.08.2010, p. 2917-2933.

Research output: Contribution to journalArticle

Dacks, Andrew M. ; Reisenman, Carolina E. ; Paulk, Angelique C. ; Nighorn, Alan J. / Histamine-immunoreactive local neurons in the antennal lobes of the hymenoptera. In: Journal of Comparative Neurology. 2010 ; Vol. 518, No. 15. pp. 2917-2933.
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