Histone genes are clustered with a 15-kilobas repeat in the chicken genome

R. J. Crawford, P. Krieg, R. P. Harvey, D. A. Hewish, J. R.E. Wells

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Histone mRNA isolated from 5-day-old chick embryos has been used as a template for complementary DNA (cDNA) synthesis. The resultant cDNA, after removal of sequences complementary to rRNA, was used to detect histone genes in adult chicken genomal DNA. Hybridisation data indicate that the histone genes are repeated about 10-Fold in the chicken genome. Restriction endonuclease analysis reveals some sequence heterogeneity in these genes. However, the results show that chicken histone genes are clustered with a basic repeat unit of 15 kilobases.

Original languageEnglish (US)
Pages (from-to)132-136
Number of pages5
JournalNature
Volume279
Issue number5709
DOIs
StatePublished - Dec 1 1979
Externally publishedYes

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Histone genes are clustered with a 15-kilobas repeat in the chicken genome'. Together they form a unique fingerprint.

  • Cite this

    Crawford, R. J., Krieg, P., Harvey, R. P., Hewish, D. A., & Wells, J. R. E. (1979). Histone genes are clustered with a 15-kilobas repeat in the chicken genome. Nature, 279(5709), 132-136. https://doi.org/10.1038/279132a0