Histone genes are clustered with a 15-kilobas repeat in the chicken genome

R. J. Crawford, Paul A Krieg, R. P. Harvey, D. A. Hewish, J. R E Wells

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Histone mRNA isolated from 5-day-old chick embryos has been used as a template for complementary DNA (cDNA) synthesis. The resultant cDNA, after removal of sequences complementary to rRNA, was used to detect histone genes in adult chicken genomal DNA. Hybridisation data indicate that the histone genes are repeated about 10-Fold in the chicken genome. Restriction endonuclease analysis reveals some sequence heterogeneity in these genes. However, the results show that chicken histone genes are clustered with a basic repeat unit of 15 kilobases.

Original languageEnglish (US)
Pages (from-to)132-136
Number of pages5
JournalNature
Volume279
Issue number5709
DOIs
StatePublished - 1979
Externally publishedYes

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Histones
Chickens
Genome
Genes
Complementary DNA
DNA Restriction Enzymes
Chick Embryo
Messenger RNA
DNA

ASJC Scopus subject areas

  • General

Cite this

Crawford, R. J., Krieg, P. A., Harvey, R. P., Hewish, D. A., & Wells, J. R. E. (1979). Histone genes are clustered with a 15-kilobas repeat in the chicken genome. Nature, 279(5709), 132-136. https://doi.org/10.1038/279132a0

Histone genes are clustered with a 15-kilobas repeat in the chicken genome. / Crawford, R. J.; Krieg, Paul A; Harvey, R. P.; Hewish, D. A.; Wells, J. R E.

In: Nature, Vol. 279, No. 5709, 1979, p. 132-136.

Research output: Contribution to journalArticle

Crawford, RJ, Krieg, PA, Harvey, RP, Hewish, DA & Wells, JRE 1979, 'Histone genes are clustered with a 15-kilobas repeat in the chicken genome', Nature, vol. 279, no. 5709, pp. 132-136. https://doi.org/10.1038/279132a0
Crawford, R. J. ; Krieg, Paul A ; Harvey, R. P. ; Hewish, D. A. ; Wells, J. R E. / Histone genes are clustered with a 15-kilobas repeat in the chicken genome. In: Nature. 1979 ; Vol. 279, No. 5709. pp. 132-136.
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