Histopathology of optic nerve pit-associated maculopathy

John B Christoforidis, William Terrell, Frederick H. Davidorf

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Purpose: To describe the histopathologic findings of an eye bank specimen containing an optic nerve pit with associated serous elevation of the macula and cavernous atrophy of the optic nerve. Methods: An eye bank specimen found to have an optic nerve pit with serous elevation of the macula was grossly examined and photographed. The globe was processed for both light and scanning electron microscopy. Results: The scanning electron microscopic study of this eye with an optic nerve pit revealed holes in the diaphanous membrane overlying the nerve at the edge of the optic pit. Serial histopathology sections revealed a connection between the holes overlying the optic pit and the subretinal space via a schisis-like cavity in the retina. Conclusion: The discovery of an optic nerve pit with coexisting serous detachment of the macula in an eye bank eye and subsequent pathological evaluation provides support for current theories into the mechanism of the visual loss in this condition. Our finding supports syneretic vitreous to be the source of the subretinal fluid.

Original languageEnglish (US)
Pages (from-to)1169-1174
Number of pages6
JournalClinical Ophthalmology
Volume6
Issue number1
DOIs
StatePublished - Jul 24 2012
Externally publishedYes

Fingerprint

Optic Nerve
Eye Banks
Subretinal Fluid
Electron Scanning Microscopy
Atrophy
Retina
Electrons
Light
Membranes

Keywords

  • Electron microscopy
  • Light microscopy
  • Optic nerve pit
  • Retinal detachment

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Histopathology of optic nerve pit-associated maculopathy. / Christoforidis, John B; Terrell, William; Davidorf, Frederick H.

In: Clinical Ophthalmology, Vol. 6, No. 1, 24.07.2012, p. 1169-1174.

Research output: Contribution to journalArticle

Christoforidis, John B ; Terrell, William ; Davidorf, Frederick H. / Histopathology of optic nerve pit-associated maculopathy. In: Clinical Ophthalmology. 2012 ; Vol. 6, No. 1. pp. 1169-1174.
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