Histoplasmosis-associated cross-reactivity in the biorad platelia Aspergillus enzyme immunoassay

L. Joseph Wheat, Emily Hackett, Michelle Durkin, Patricia Connolly, Ruta Petraitiene, Thomas J. Walsh, Kenneth Knox, Chadi Hage

Research output: Contribution to journalArticle

106 Scopus citations

Abstract

We observed false-positive results in the Platelia Aspergillus enzyme-linked immunoassay (EIA) for specimens from patients with histoplasmosis and mice with experimental infection. Platelia Aspergillus EIA-positive specimens were negative in the second-generation Histoplasma antigen EIA. Care must be taken to exclude histoplasmosis for patients with positive Platelia Aspergillus EIA results.

Original languageEnglish (US)
Pages (from-to)638-640
Number of pages3
JournalClinical and Vaccine Immunology
Volume14
Issue number5
DOIs
StatePublished - May 1 2007

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)

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    Wheat, L. J., Hackett, E., Durkin, M., Connolly, P., Petraitiene, R., Walsh, T. J., Knox, K., & Hage, C. (2007). Histoplasmosis-associated cross-reactivity in the biorad platelia Aspergillus enzyme immunoassay. Clinical and Vaccine Immunology, 14(5), 638-640. https://doi.org/10.1128/CVI.00479-06