HIV antigens can induce TGF-β1-producing immunoregulatory CD8+ T cells

Mohammed L. Garba, Christopher D. Pilcher, Andrea L. Bingham, Joseph Eron, Jeffrey A. Frelinger

Research output: Contribution to journalArticlepeer-review

116 Scopus citations

Abstract

HIV-infected individuals may progressively lose both HIV-specific and unrelated CTL responses despite the high number of circulating CD8+ T cells. In this study, we report that ∼25% of HIV+ donors produced TGF-β1 in response to stimulation with HIV proteins or peptides. The production of TGF-β1 was sufficient to significantly reduce the IFN-γ response of CD8+ cells to both HIV and vaccinia virus proteins. Ab to TGF-β reversed the suppression. We found the source of the TGF-β1 to be predominantly CD8+ cells. Different peptide pools stimulated TGF-β1 and IFN-γ in the same individual. The TGF-β1 secreting cells have distinct peptide specificity from the IFN-γ producing cells. This represents an important mechanism by which an HIV-specific response can nonspecifically suppress both HIV-specific and unrelated immune responses.

Original languageEnglish (US)
Pages (from-to)2247-2254
Number of pages8
JournalJournal of Immunology
Volume168
Issue number5
DOIs
StatePublished - Mar 1 2002

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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