HIV antigens can induce TGF-β1-producing immunoregulatory CD8+ T cells

Mohammed L. Garba, Christopher D. Pilcher, Andrea L. Bingham, Joseph Eron, Jeffrey A Frelinger

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

HIV-infected individuals may progressively lose both HIV-specific and unrelated CTL responses despite the high number of circulating CD8+ T cells. In this study, we report that ∼25% of HIV+ donors produced TGF-β1 in response to stimulation with HIV proteins or peptides. The production of TGF-β1 was sufficient to significantly reduce the IFN-γ response of CD8+ cells to both HIV and vaccinia virus proteins. Ab to TGF-β reversed the suppression. We found the source of the TGF-β1 to be predominantly CD8+ cells. Different peptide pools stimulated TGF-β1 and IFN-γ in the same individual. The TGF-β1 secreting cells have distinct peptide specificity from the IFN-γ producing cells. This represents an important mechanism by which an HIV-specific response can nonspecifically suppress both HIV-specific and unrelated immune responses.

Original languageEnglish (US)
Pages (from-to)2247-2254
Number of pages8
JournalJournal of Immunology
Volume168
Issue number5
StatePublished - Mar 1 2002
Externally publishedYes

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HIV Antigens
HIV
T-Lymphocytes
Peptides
Human Immunodeficiency Virus Proteins
Vaccinia virus

ASJC Scopus subject areas

  • Immunology

Cite this

Garba, M. L., Pilcher, C. D., Bingham, A. L., Eron, J., & Frelinger, J. A. (2002). HIV antigens can induce TGF-β1-producing immunoregulatory CD8+ T cells. Journal of Immunology, 168(5), 2247-2254.

HIV antigens can induce TGF-β1-producing immunoregulatory CD8+ T cells. / Garba, Mohammed L.; Pilcher, Christopher D.; Bingham, Andrea L.; Eron, Joseph; Frelinger, Jeffrey A.

In: Journal of Immunology, Vol. 168, No. 5, 01.03.2002, p. 2247-2254.

Research output: Contribution to journalArticle

Garba, ML, Pilcher, CD, Bingham, AL, Eron, J & Frelinger, JA 2002, 'HIV antigens can induce TGF-β1-producing immunoregulatory CD8+ T cells', Journal of Immunology, vol. 168, no. 5, pp. 2247-2254.
Garba ML, Pilcher CD, Bingham AL, Eron J, Frelinger JA. HIV antigens can induce TGF-β1-producing immunoregulatory CD8+ T cells. Journal of Immunology. 2002 Mar 1;168(5):2247-2254.
Garba, Mohammed L. ; Pilcher, Christopher D. ; Bingham, Andrea L. ; Eron, Joseph ; Frelinger, Jeffrey A. / HIV antigens can induce TGF-β1-producing immunoregulatory CD8+ T cells. In: Journal of Immunology. 2002 ; Vol. 168, No. 5. pp. 2247-2254.
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