HIV antigens can induce TGF-β1-producing immunoregulatory CD8+ T cells

Mohammed L. Garba, Christopher D. Pilcher, Andrea L. Bingham, Joseph Eron, Jeffrey A Frelinger

Research output: Contribution to journalArticle

115 Scopus citations

Abstract

HIV-infected individuals may progressively lose both HIV-specific and unrelated CTL responses despite the high number of circulating CD8+ T cells. In this study, we report that ∼25% of HIV+ donors produced TGF-β1 in response to stimulation with HIV proteins or peptides. The production of TGF-β1 was sufficient to significantly reduce the IFN-γ response of CD8+ cells to both HIV and vaccinia virus proteins. Ab to TGF-β reversed the suppression. We found the source of the TGF-β1 to be predominantly CD8+ cells. Different peptide pools stimulated TGF-β1 and IFN-γ in the same individual. The TGF-β1 secreting cells have distinct peptide specificity from the IFN-γ producing cells. This represents an important mechanism by which an HIV-specific response can nonspecifically suppress both HIV-specific and unrelated immune responses.

Original languageEnglish (US)
Pages (from-to)2247-2254
Number of pages8
JournalJournal of Immunology
Volume168
Issue number5
Publication statusPublished - Mar 1 2002
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Immunology

Cite this

Garba, M. L., Pilcher, C. D., Bingham, A. L., Eron, J., & Frelinger, J. A. (2002). HIV antigens can induce TGF-β1-producing immunoregulatory CD8+ T cells. Journal of Immunology, 168(5), 2247-2254.